Universität zu Köln

Engeli, Stefan, May, Marcus ORCID: 0000-0002-7513-4244, Nussberger, Juerg, Danser, A. H. Jan, Dole, William P., Prescott, Margaret F., Dahlke, Marion, Stitah, Sylvie, Pal, Parasar, Boschmann, Michael and Jordan, Jens (2017). Systemic and tissue-specific effects of aliskiren on the RAAS and carbohydrate/lipid metabolism in obese patients with hypertension. J. Am. Soc. Hypertens., 11 (8). S. 488 - 498. NEW YORK: ELSEVIER SCIENCE INC. ISSN 1878-7436

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Abstract

Aliskiren penetrates adipose and skeletal muscle in hypertensive patients with abdominal obesity and reduces renin angiotensin aldosterone system activity. After discontinuation, blood pressure lowering effects are observed possibly through drug tissue binding. We performed microdialysis evaluation of adipose tissue and skeletal muscle before and during an insulin-modified frequently sampled intravenous glucose tolerance test (IM-FSIGT). Aliskiren 300 mg (n = 8) or amlodipine 5 mg (n = 8) once daily were administered during a 12-week randomized treatment period. Aliskiren elicited variable changes in median interstitial angiotensin II (Ang II) in adipose (2.60-1.30 fmol/mL) and skeletal muscle (2.23-0.68 fmol/mL); amlodipine tended to increase adipose and skeletal muscle Ang II (P=.066 for skeletal muscle treatment difference). Glucose/insulin increased median plasma Ang II 1 hour after glucose injection (1.04-2.50 fmol/mL; P=.001), which was markedly attenuated by aliskiren but not amlodipine. Aliskiren increased glucose disposition index (P=.012) and tended to increase acute insulin response to glucose (P=.067). Fasting adipose glycerol (-17%; P=.064) and fasting muscle glucose dialysate (-17%; P=.025) were decreased by aliskiren but not amlodipine. In summary, aliskiren decreased Ang II production in response to glucose/insulin stimulus and elicited metabolic effects in adipose and skeletal muscle suggestive of increased whole-body glucose utilization. (C) 2017 American Society of Hypertension. All rights reserved.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Engeli, Stefan UNSPECIFIED UNSPECIFIED UNSPECIFIED May, Marcus UNSPECIFIED orcid.org/0000-0002-7513-4244 UNSPECIFIED Nussberger, Juerg UNSPECIFIED UNSPECIFIED UNSPECIFIED Danser, A. H. Jan UNSPECIFIED UNSPECIFIED UNSPECIFIED Dole, William P. UNSPECIFIED UNSPECIFIED UNSPECIFIED Prescott, Margaret F. UNSPECIFIED UNSPECIFIED UNSPECIFIED Dahlke, Marion UNSPECIFIED UNSPECIFIED UNSPECIFIED Stitah, Sylvie UNSPECIFIED UNSPECIFIED UNSPECIFIED Pal, Parasar UNSPECIFIED UNSPECIFIED UNSPECIFIED Boschmann, Michael UNSPECIFIED UNSPECIFIED UNSPECIFIED Jordan, Jens UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-222738
DOI:	10.1016/j.jash.2017.06.002
Journal or Publication Title:	J. Am. Soc. Hypertens.
Volume:	11
Number:	8
Page Range:	S. 488 - 498
Date:	2017
Publisher:	ELSEVIER SCIENCE INC
Place of Publication:	NEW YORK
ISSN:	1878-7436
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language RENIN-ANGIOTENSIN SYSTEM; INSULIN-RESISTANCE; SUBCUTANEOUS ADIPOCYTES; INHIBITION; GLUCOSE; ADIPOSE; HUMANS; MODEL; HYDROCHLOROTHIAZIDE; METAANALYSIS Multiple languages Peripheral Vascular Disease Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/22273