Universität zu Köln

Savio, Alexandre ORCID: 0000-0002-6608-6885, Fuenger, Sarah, Tahmasian, Masoud ORCID: 0000-0003-3999-3807, Rachakonda, Srinivas, Manoliu, Andrei, Sorg, Christian, Grimmer, Timo, Calhoun, Vince, Drzezga, Alexander, Riedl, Valentin ORCID: 0000-0002-2861-8449 and Yakushev, Igor (2017). Resting-State Networks as Simultaneously Measured with Functional MRI and PET. J. Nucl. Med., 58 (8). S. 1314 - 1318. RESTON: SOC NUCLEAR MEDICINE INC. ISSN 1535-5667

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Abstract

Functional MRI (fMRI) studies reported disruption of resting-state networks (RSNs) in several neuropsychiatric disorders. PET with F-18-FDG captures neuronal activity that is in steady state at a longer time span and is less dependent on neurovascular coupling. Methods: In the present study, we aimed to identify RSNs in F-18-FDG PET data and compare their spatial pattern with those obtained from simultaneously acquired resting-state fMRI data in 22 middle-aged healthy subjects. Results: Thirteen and 17 meaningful RSNs could be identified in PET and fMRI data, respectively. Spatial overlap was fair tomoderate for the defaultmode, left central executive, primary and secondary visual, sensorimotor, cerebellar, and auditory networks. Despite recording different aspects of neural activity, similar RSNs were detected by both imaging modalities. Conclusion: The results argue for the common neural substrate of RSNs and encourage testing of the clinical utility of resting-state connectivity in PET data.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Savio, Alexandre UNSPECIFIED orcid.org/0000-0002-6608-6885 UNSPECIFIED Fuenger, Sarah UNSPECIFIED UNSPECIFIED UNSPECIFIED Tahmasian, Masoud UNSPECIFIED orcid.org/0000-0003-3999-3807 UNSPECIFIED Rachakonda, Srinivas UNSPECIFIED UNSPECIFIED UNSPECIFIED Manoliu, Andrei UNSPECIFIED UNSPECIFIED UNSPECIFIED Sorg, Christian UNSPECIFIED UNSPECIFIED UNSPECIFIED Grimmer, Timo UNSPECIFIED UNSPECIFIED UNSPECIFIED Calhoun, Vince UNSPECIFIED UNSPECIFIED UNSPECIFIED Drzezga, Alexander UNSPECIFIED UNSPECIFIED UNSPECIFIED Riedl, Valentin UNSPECIFIED orcid.org/0000-0002-2861-8449 UNSPECIFIED Yakushev, Igor UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-223130
DOI:	10.2967/jnumed.116.185835
Journal or Publication Title:	J. Nucl. Med.
Volume:	58
Number:	8
Page Range:	S. 1314 - 1318
Date:	2017
Publisher:	SOC NUCLEAR MEDICINE INC
Place of Publication:	RESTON
ISSN:	1535-5667
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language INDEPENDENT COMPONENT ANALYSIS; GLUCOSE-UTILIZATION; HUMAN BRAIN; CONNECTIVITY; FDG; SEGMENTATION; PERFORMANCE; SELECTION; PATTERNS; TOOL Multiple languages Radiology, Nuclear Medicine & Medical Imaging Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/22313