Strenger, Volker, Farowski, Fedja, Mueller, Carsten, Hofer, Nora, Dornbusch, Hans Juergen, Sperl, Daniela, Lackner, Herwig, Benesch, Martin and Urban, Christian (2017). Low penetration of caspofungin into cerebrospinal fluid following intravenous administration of standard doses. Int. J. Antimicrob. Agents, 50 (2). S. 272 - 276. AMSTERDAM: ELSEVIER SCIENCE BV. ISSN 1872-7913
Full text not available from this repository.Abstract
The kinetics of caspofungin (CAS) in cerebrospinal fluid (CSF) following intravenous (i.v.) administration has been studied exclusively in animal models. Human data are missing so far. In this study, 13 CSF samples were obtained at different time points following i.v. infusion of CAS in ten paediatric haemato-/oncological patients (age range 1.0-14.2 years, median 8.6 years) without signs of central nervous system (CNS) infection (n = 10 samples) or with infectious meningitis (n = 3 samples). Serum samples were obtained concurrently. Liquid chromatography-tandem mass spectrometry was used for CAS quantification. Whilst CAS serum levels were in the expected range, varying between 0.6 and 20.3 mu g/mL (median 7.0 mu g/mL), 11 of 13 CSF levels were below the limit of detection of 0.084 mu g/mL at 3.0-48.0 h (median 23.3 h) following i.v. infusion. Only two (of three) levels in patients with bacterial meningitis were above the limit of detection (0.3 mu g/mL and 0.09 mu g/mL, respectively). These results indicate the low capacity of CAS to penetrate into the CNS even in inflamed meninges. Monotherapy with standard doses of CAS appears not to be suitable for treatment of fungal CNS infections. (C) 2017 Elsevier B.V. and International Society of Chemotherapy. All rights reserved.
| Item Type: | Journal Article | ||||||||||||||||||||||||||||||||||||||||
| Creators: |
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| URN: | urn:nbn:de:hbz:38-223339 | ||||||||||||||||||||||||||||||||||||||||
| DOI: | 10.1016/j.ijantimicag.2017.02.024 | ||||||||||||||||||||||||||||||||||||||||
| Journal or Publication Title: | Int. J. Antimicrob. Agents | ||||||||||||||||||||||||||||||||||||||||
| Volume: | 50 | ||||||||||||||||||||||||||||||||||||||||
| Number: | 2 | ||||||||||||||||||||||||||||||||||||||||
| Page Range: | S. 272 - 276 | ||||||||||||||||||||||||||||||||||||||||
| Date: | 2017 | ||||||||||||||||||||||||||||||||||||||||
| Publisher: | ELSEVIER SCIENCE BV | ||||||||||||||||||||||||||||||||||||||||
| Place of Publication: | AMSTERDAM | ||||||||||||||||||||||||||||||||||||||||
| ISSN: | 1872-7913 | ||||||||||||||||||||||||||||||||||||||||
| Language: | English | ||||||||||||||||||||||||||||||||||||||||
| Faculty: | Unspecified | ||||||||||||||||||||||||||||||||||||||||
| Divisions: | Unspecified | ||||||||||||||||||||||||||||||||||||||||
| Subjects: | no entry | ||||||||||||||||||||||||||||||||||||||||
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| Refereed: | Yes | ||||||||||||||||||||||||||||||||||||||||
| URI: | http://kups.ub.uni-koeln.de/id/eprint/22333 |
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