Universität zu Köln

Rietschel, Liz, Lambert, Martin, Karow, Anne, Zink, Mathias, Mueller, Hendrik, Heinz, Andreas ORCID: 0000-0001-5405-9065, de Millas, Walter, Janssen, Birgit, Gaebel, Wolfgang, Schneider, Frank ORCID: 0000-0003-1557-7956, Naber, Dieter, Juckel, Georg, Krueger-Oezguerdal, Seza, Wobrock, Thomas, Wagner, Michael ORCID: 0000-0003-2589-6440, Maier, Wolfgang, Klosterkoetter, Joachim and Bechdolf, Andreas (2017). Clinical high risk for psychosis: gender differences in symptoms and social functioning. Early Interv. Psychiatry, 11 (4). S. 306 - 314. HOBOKEN: WILEY. ISSN 1751-7893

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Abstract

AimSchizophrenia is a heterogeneous disorder that presents differently in men and women: men show a higher propensity to negative symptoms, lower social functioning, earlier age at onset and co-morbid substance abuse, whereas women display more affective symptoms. It is unknown whether these differences extend to subjects at high risk (HR) of psychosis. Thus, the aim of the present study was to address this question. MethodsClinical symptoms and functioning were assessed using structured interviews in 239 HR subjects (female, n=80). The definition of being at HR was based on the criteria used in the European Prediction of Psychosis Study (EPOS). ResultsMen displayed more pronounced negative symptoms, higher rates of past substance abuse disorders and higher deficits in social functioning. No gender difference was found for depression, which affected almost 50% of the cohort, or age at onset for the fulfilment of HR criteria. ConclusionThe higher impairment in specific symptoms observed in male schizophrenia patients was also present in subjects at HR for psychosis. Further studies are required to determine whether these symptoms are gender-specific predictors of transition to psychosis and whether they warrant gender-specific interventions. The high propensity to depression in the present cohort, which was particularly pronounced in the male cohort compared with the general population, in conjunction with the observed increase in negative symptoms and functional impairment, should alert clinicians to the necessity for the identification and treatment of HR subjects, irrespective of the degree to which these features are associated with transition risk.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Rietschel, Liz UNSPECIFIED UNSPECIFIED UNSPECIFIED Lambert, Martin UNSPECIFIED UNSPECIFIED UNSPECIFIED Karow, Anne UNSPECIFIED UNSPECIFIED UNSPECIFIED Zink, Mathias UNSPECIFIED UNSPECIFIED UNSPECIFIED Mueller, Hendrik UNSPECIFIED UNSPECIFIED UNSPECIFIED Heinz, Andreas UNSPECIFIED orcid.org/0000-0001-5405-9065 UNSPECIFIED de Millas, Walter UNSPECIFIED UNSPECIFIED UNSPECIFIED Janssen, Birgit UNSPECIFIED UNSPECIFIED UNSPECIFIED Gaebel, Wolfgang UNSPECIFIED UNSPECIFIED UNSPECIFIED Schneider, Frank UNSPECIFIED orcid.org/0000-0003-1557-7956 UNSPECIFIED Naber, Dieter UNSPECIFIED UNSPECIFIED UNSPECIFIED Juckel, Georg UNSPECIFIED UNSPECIFIED UNSPECIFIED Krueger-Oezguerdal, Seza UNSPECIFIED UNSPECIFIED UNSPECIFIED Wobrock, Thomas UNSPECIFIED UNSPECIFIED UNSPECIFIED Wagner, Michael UNSPECIFIED orcid.org/0000-0003-2589-6440 UNSPECIFIED Maier, Wolfgang UNSPECIFIED UNSPECIFIED UNSPECIFIED Klosterkoetter, Joachim UNSPECIFIED UNSPECIFIED UNSPECIFIED Bechdolf, Andreas UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-223528
DOI:	10.1111/eip.12240
Journal or Publication Title:	Early Interv. Psychiatry
Volume:	11
Number:	4
Page Range:	S. 306 - 314
Date:	2017
Publisher:	WILEY
Place of Publication:	HOBOKEN
ISSN:	1751-7893
Language:	English
Faculty:	Faculty of Management, Economy and Social Sciences
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language SEX-DIFFERENCES; 1ST-EPISODE PSYCHOSIS; DEPRESSION; PREDICTION; SCHIZOPHRENIA; METAANALYSIS; PREVALENCE; ADJUSTMENT; CONVERSION; PRODROME Multiple languages Psychiatry Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/22352