Rietschel, Liz, Lambert, Martin, Karow, Anne, Zink, Mathias, Mueller, Hendrik, Heinz, Andreas ORCID: 0000-0001-5405-9065, de Millas, Walter, Janssen, Birgit, Gaebel, Wolfgang, Schneider, Frank ORCID: 0000-0003-1557-7956, Naber, Dieter, Juckel, Georg, Krueger-Oezguerdal, Seza, Wobrock, Thomas, Wagner, Michael ORCID: 0000-0003-2589-6440, Maier, Wolfgang, Klosterkoetter, Joachim and Bechdolf, Andreas (2017). Clinical high risk for psychosis: gender differences in symptoms and social functioning. Early Interv. Psychiatry, 11 (4). S. 306 - 314. HOBOKEN: WILEY. ISSN 1751-7893

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Abstract

AimSchizophrenia is a heterogeneous disorder that presents differently in men and women: men show a higher propensity to negative symptoms, lower social functioning, earlier age at onset and co-morbid substance abuse, whereas women display more affective symptoms. It is unknown whether these differences extend to subjects at high risk (HR) of psychosis. Thus, the aim of the present study was to address this question. MethodsClinical symptoms and functioning were assessed using structured interviews in 239 HR subjects (female, n=80). The definition of being at HR was based on the criteria used in the European Prediction of Psychosis Study (EPOS). ResultsMen displayed more pronounced negative symptoms, higher rates of past substance abuse disorders and higher deficits in social functioning. No gender difference was found for depression, which affected almost 50% of the cohort, or age at onset for the fulfilment of HR criteria. ConclusionThe higher impairment in specific symptoms observed in male schizophrenia patients was also present in subjects at HR for psychosis. Further studies are required to determine whether these symptoms are gender-specific predictors of transition to psychosis and whether they warrant gender-specific interventions. The high propensity to depression in the present cohort, which was particularly pronounced in the male cohort compared with the general population, in conjunction with the observed increase in negative symptoms and functional impairment, should alert clinicians to the necessity for the identification and treatment of HR subjects, irrespective of the degree to which these features are associated with transition risk.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Rietschel, LizUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lambert, MartinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Karow, AnneUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Zink, MathiasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mueller, HendrikUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Heinz, AndreasUNSPECIFIEDorcid.org/0000-0001-5405-9065UNSPECIFIED
de Millas, WalterUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Janssen, BirgitUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gaebel, WolfgangUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schneider, FrankUNSPECIFIEDorcid.org/0000-0003-1557-7956UNSPECIFIED
Naber, DieterUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Juckel, GeorgUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Krueger-Oezguerdal, SezaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wobrock, ThomasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wagner, MichaelUNSPECIFIEDorcid.org/0000-0003-2589-6440UNSPECIFIED
Maier, WolfgangUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Klosterkoetter, JoachimUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bechdolf, AndreasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-223528
DOI: 10.1111/eip.12240
Journal or Publication Title: Early Interv. Psychiatry
Volume: 11
Number: 4
Page Range: S. 306 - 314
Date: 2017
Publisher: WILEY
Place of Publication: HOBOKEN
ISSN: 1751-7893
Language: English
Faculty: Faculty of Management, Economy and Social Sciences
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
SEX-DIFFERENCES; 1ST-EPISODE PSYCHOSIS; DEPRESSION; PREDICTION; SCHIZOPHRENIA; METAANALYSIS; PREVALENCE; ADJUSTMENT; CONVERSION; PRODROMEMultiple languages
PsychiatryMultiple languages
Refereed: Yes
URI: http://kups.ub.uni-koeln.de/id/eprint/22352

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