Universität zu Köln

Miroshnikova, Yekaterina A., Nava, Michele M. ORCID: 0000-0001-8733-6364 and Wickstroem, Sara A. (2017). Emerging roles of mechanical forces in chromatin regulation. J. Cell Sci., 130 (14). S. 2243 - 2251. CAMBRIDGE: COMPANY BIOLOGISTS LTD. ISSN 1477-9137

Full text not available from this repository.

Abstract

Cells are constantly subjected to a spectrum of mechanical cues, such as shear stress, compression, differential tissue rigidity and strain, to which they adapt by engaging mechanisms of mechanotransduction. While the central role of cell adhesion receptors in this process is established, it has only recently been appreciated that mechanical cues reach far beyond the plasma membrane and the cytoskeleton, and are directly transmitted to the nucleus. Furthermore, changes in the mechanical properties of the perinuclear cytoskeleton, nuclear lamina and chromatin are critical for cellular responses and adaptation to external mechanical cues. In that respect, dynamic changes in the nuclear lamina and the surrounding cytoskeleton modify mechanical properties of the nucleus, thereby protecting genetic material from damage. The importance of this mechanism is highlighted by debilitating genetic diseases, termed laminopathies, that result from impaired mechanoresistance of the nuclear lamina. What has been less evident, and represents one of the exciting emerging concepts, is that chromatin itself is an active rheological element of the nucleus, which undergoes dynamic changes upon application of force, thereby facilitating cellular adaption to differential force environments. This Review aims to highlight these emerging concepts by discussing the latest literature in this area and by proposing an integrative model of cytoskeletal and chromatin-mediated responses to mechanical stress.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Miroshnikova, Yekaterina A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Nava, Michele M. UNSPECIFIED orcid.org/0000-0001-8733-6364 UNSPECIFIED Wickstroem, Sara A. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-224999
DOI:	10.1242/jcs.202192
Journal or Publication Title:	J. Cell Sci.
Volume:	130
Number:	14
Page Range:	S. 2243 - 2251
Date:	2017
Publisher:	COMPANY BIOLOGISTS LTD
Place of Publication:	CAMBRIDGE
ISSN:	1477-9137
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language NUCLEAR-ENVELOPE; ACTIN DYNAMICS; CELL-MIGRATION; DNA-DAMAGE; STEM-CELLS; LAMIN A/C; ARCHITECTURE; MECHANOTRANSDUCTION; NUCLEOSKELETON; ORGANIZATION Multiple languages Cell Biology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/22499