Lecarpentier, Julie, Silvestri, Valentina ORCID: 0000-0003-0712-9379, Kuchenbaecker, Karoline B., Barrowdale, Daniel ORCID: 0000-0003-1661-3939, Dennis, Joe, McGuffog, Lesley, Soucy, Penny, Leslie, Goska ORCID: 0000-0001-5756-6222, Rizzolo, Piera ORCID: 0000-0002-3421-1485, Navazio, Anna Sara, Valentini, Virginia, Zelli, Veronica, Lee, Andrew, Al Olama, Ali Amin, Tyrer, Jonathan P., Southey, Melissa ORCID: 0000-0002-6313-9005, John, Esther M., Conner, Thomas A., Goldgar, David E., Buys, Saundra S., Janavicius, Ramunas, Steele, Linda, Ding, Yuan Chun, Neuhausen, Susan L., Hansen, Thomas V. O., Osorio, Ana ORCID: 0000-0001-8124-3984, Weitzel, Jeffrey N., Toss, Angela, Medici, Veronica, Cortesi, Laura, Zanna, Ines ORCID: 0000-0002-5710-6506, Palli, Domenico, Radice, Paolo ORCID: 0000-0001-6298-4111, Manoukian, Siranoush, Peissel, Bernard, Azzollini, Jacopo ORCID: 0000-0002-9364-9778, Viel, Alessandra ORCID: 0000-0003-2804-0840, Cini, Giulia ORCID: 0000-0002-8696-8922, Damante, Giuseppe, Tommasi, Stefania, Peterlongo, Paolo ORCID: 0000-0001-6951-6855, Fostira, Florentia, Hamann, Ute, Evans, D. Gareth, Henderson, Alex, Brewer, Carole, Eccles, Diana ORCID: 0000-0002-9935-3169, Cook, Jackie, Ong, Kai-ren, Walker, Lisa, Side, Lucy E., Porteous, Mary E., Davidson, Rosemarie, Hodgson, Shirley, Frost, Debra, Adlard, Julian ORCID: 0000-0002-1693-0435, Izatt, Louise, Eeles, Ros, Ellis, Steve, Tischkowitz, Marc ORCID: 0000-0002-7880-0628, Godwin, Andrew K., Meindl, Alfons, Gehrig, Andrea, Dworniczak, Bernd, Sutter, Christian, Engel, Christoph ORCID: 0000-0002-7247-282X, Niederacher, Dieter, Steinemann, Doris, Hahnen, Eric, Hauke, Jan, Rhiem, Kerstin, Kast, Karin, Arnold, Norbert ORCID: 0000-0003-4523-8808, Ditsch, Nina, Wang-Gohrke, Shan, Wappenschmidt, Barbara, Wand, Dorothea, Lasset, Christine, Stoppa-Lyonnet, Dominique, Belotti, Muriel, Damiola, Francesca ORCID: 0000-0002-0238-1252, Barjhoux, Laure, Mazoyer, Sylvie ORCID: 0000-0002-2135-0160, Van Heetvelde, Mattias, Poppe, Bruce, De Leeneer, Kim, Claes, Kathleen B. M., de la Hoya, Miguel ORCID: 0000-0002-8113-1410, Garcia-Barberan, Vanesa, Caldes, Trinidad, Perez Segura, Pedro, Kiiski, Johanna I. ORCID: 0000-0002-4089-7209, Aittomaeki, Kristiina, Khan, Sofia ORCID: 0000-0003-4185-8882, Nevanlinna, Heli, van Asperen, Christi J., Vaszko, Tibor, Kasler, Miklos, Olah, Edith, Balmana, Judith ORCID: 0000-0002-0762-6415, Gutierrez-Enriquez, Sara ORCID: 0000-0002-1711-6101, Diez, Orland, Teule, Alex ORCID: 0000-0003-0028-7200, Izquierdo, Angel, Darder, Esther, Brunet, Joan ORCID: 0000-0003-1945-3512, Del Valle, Jesus, Feliubadalo, Lidia ORCID: 0000-0002-1736-0112, Pujana, Miquel Angel, Lazaro, Conxi, Arason, Adalgeir, Agnarsson, Bjarni A., Johannsson, Oskar Th., Barkardottir, Rosa B., Alducci, Elisa, Tognazzo, Silvia ORCID: 0000-0002-6260-1261, Montagna, Marco, Teixeira, Manuel R., Pinto, Pedro ORCID: 0000-0001-6289-5792, Spurdle, Amanda B., Holland, Helene, Lee, Jong Won, Lee, Min Hyuk, Lee, Jihyoun, Kim, Sung-Won, Kang, Eunyoung, Kim, Zisun, Sharma, Priyanka ORCID: 0000-0001-8592-2239, Rebbeck, Timothy R., Vijai, Joseph, Robson, Mark, Lincoln, Anne, Musinsky, Jacob, Gaddam, Pragna, Tan, Yen Y., Berger, Andreas, Singer, Christian F., Loud, Jennifer T., Greene, Mark H., Mulligan, Anna Marie ORCID: 0000-0002-7239-5297, Glendon, Gord, Andrulis, Irene L., Toland, Amanda Ewart, Senter, Leigha ORCID: 0000-0001-9270-8847, Bojesen, Anders ORCID: 0000-0003-4289-8595, Nielsen, Henriette Roed, Skytte, Anne-Bine ORCID: 0000-0002-0067-9557, Sunde, Lone ORCID: 0000-0002-8479-165X, Jensen, Uffe Birk ORCID: 0000-0002-6205-6355, Pedersen, Inge Sokilde ORCID: 0000-0002-9902-8040, Krogh, Lotte, Kruse, Torben A., Caligo, Maria A., Yoon, Sook-Yee, Teo, Soo-Hwang, von Wachenfeldt, Anna, Huo, Dezheng, Nielsen, Sarah M., Olopade, Olufunmilayo I., Nathanson, Katherine L., Domchek, Susan M., Lorenchick, Christa, Jankowitz, Rachel C., Campbell, Ian ORCID: 0000-0002-7773-4155, James, Paul ORCID: 0000-0002-4361-4657, Mitchell, Gillian, Orr, Nick, Park, Sue Kyung, Thomassen, Mads, Offit, Kenneth, Couch, Fergus J., Simard, Jacques, Easton, Douglas F., Chenevix-Trench, Georgia ORCID: 0000-0002-1878-2587, Schmutzler, Rita K., Antoniou, Antonis C. and Ottini, Laura (2017). Prediction of Breast and Prostate Cancer Risks in Male BRCA1 and BRCA2 Mutation Carriers Using Polygenic Risk Scores. J. Clin. Oncol., 35 (20). S. 2240 - 2257. ALEXANDRIA: AMER SOC CLINICAL ONCOLOGY. ISSN 1527-7755

Full text not available from this repository.

Abstract

PurposeBRCA1/2 mutations increase the risk of breast and prostate cancer in men. Common genetic variants modify cancer risks for female carriers of BRCA1/2 mutations. We investigatedfor the first time to our knowledgeassociations of common genetic variants with breast and prostate cancer risks for male carriers of BRCA1/2 mutations and implications for cancer risk prediction.Materials and MethodsWe genotyped 1,802 male carriers of BRCA1/2 mutations from the Consortium of Investigators of Modifiers of BRCA1/2 by using the custom Illumina OncoArray. We investigated the combined effects of established breast and prostate cancer susceptibility variants on cancer risks for male carriers of BRCA1/2 mutations by constructing weighted polygenic risk scores (PRSs) using published effect estimates as weights.ResultsIn male carriers of BRCA1/2 mutations, PRS that was based on 88 female breast cancer susceptibility variants was associated with breast cancer risk (odds ratio per standard deviation of PRS, 1.36; 95% CI, 1.19 to 1.56; P = 8.6 x 10(-6)). Similarly, PRS that was based on 103 prostate cancer susceptibility variants was associated with prostate cancer risk (odds ratio per SD of PRS, 1.56; 95% CI, 1.35 to 1.81; P = 3.2 x 10(-9)). Large differences in absolute cancer risks were observed at the extremes of the PRS distribution. For example, prostate cancer risk by age 80 years at the 5th and 95th percentiles of the PRS varies from 7% to 26% for carriers of BRCA1 mutations and from 19% to 61% for carriers of BRCA2 mutations, respectively.ConclusionPRSs may provide informative cancer risk stratification for male carriers of BRCA1/2 mutations that might enable these men and their physicians to make informed decisions on the type and timing of breast and prostate cancer risk management.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Lecarpentier, JulieUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Silvestri, ValentinaUNSPECIFIEDorcid.org/0000-0003-0712-9379UNSPECIFIED
Kuchenbaecker, Karoline B.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Barrowdale, DanielUNSPECIFIEDorcid.org/0000-0003-1661-3939UNSPECIFIED
Dennis, JoeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
McGuffog, LesleyUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Soucy, PennyUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Leslie, GoskaUNSPECIFIEDorcid.org/0000-0001-5756-6222UNSPECIFIED
Rizzolo, PieraUNSPECIFIEDorcid.org/0000-0002-3421-1485UNSPECIFIED
Navazio, Anna SaraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Valentini, VirginiaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Zelli, VeronicaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lee, AndrewUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Al Olama, Ali AminUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Tyrer, Jonathan P.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Southey, MelissaUNSPECIFIEDorcid.org/0000-0002-6313-9005UNSPECIFIED
John, Esther M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Conner, Thomas A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Goldgar, David E.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Buys, Saundra S.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Janavicius, RamunasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Steele, LindaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ding, Yuan ChunUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Neuhausen, Susan L.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hansen, Thomas V. O.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Osorio, AnaUNSPECIFIEDorcid.org/0000-0001-8124-3984UNSPECIFIED
Weitzel, Jeffrey N.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Toss, AngelaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Medici, VeronicaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Cortesi, LauraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Zanna, InesUNSPECIFIEDorcid.org/0000-0002-5710-6506UNSPECIFIED
Palli, DomenicoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Radice, PaoloUNSPECIFIEDorcid.org/0000-0001-6298-4111UNSPECIFIED
Manoukian, SiranoushUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Peissel, BernardUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Azzollini, JacopoUNSPECIFIEDorcid.org/0000-0002-9364-9778UNSPECIFIED
Viel, AlessandraUNSPECIFIEDorcid.org/0000-0003-2804-0840UNSPECIFIED
Cini, GiuliaUNSPECIFIEDorcid.org/0000-0002-8696-8922UNSPECIFIED
Damante, GiuseppeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Tommasi, StefaniaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Peterlongo, PaoloUNSPECIFIEDorcid.org/0000-0001-6951-6855UNSPECIFIED
Fostira, FlorentiaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hamann, UteUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Evans, D. GarethUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Henderson, AlexUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Brewer, CaroleUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Eccles, DianaUNSPECIFIEDorcid.org/0000-0002-9935-3169UNSPECIFIED
Cook, JackieUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ong, Kai-renUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Walker, LisaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Side, Lucy E.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Porteous, Mary E.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Davidson, RosemarieUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hodgson, ShirleyUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Frost, DebraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Adlard, JulianUNSPECIFIEDorcid.org/0000-0002-1693-0435UNSPECIFIED
Izatt, LouiseUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Eeles, RosUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ellis, SteveUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Tischkowitz, MarcUNSPECIFIEDorcid.org/0000-0002-7880-0628UNSPECIFIED
Godwin, Andrew K.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Meindl, AlfonsUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gehrig, AndreaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Dworniczak, BerndUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sutter, ChristianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Engel, ChristophUNSPECIFIEDorcid.org/0000-0002-7247-282XUNSPECIFIED
Niederacher, DieterUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Steinemann, DorisUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hahnen, EricUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hauke, JanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rhiem, KerstinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kast, KarinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Arnold, NorbertUNSPECIFIEDorcid.org/0000-0003-4523-8808UNSPECIFIED
Ditsch, NinaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wang-Gohrke, ShanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wappenschmidt, BarbaraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wand, DorotheaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lasset, ChristineUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Stoppa-Lyonnet, DominiqueUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Belotti, MurielUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Damiola, FrancescaUNSPECIFIEDorcid.org/0000-0002-0238-1252UNSPECIFIED
Barjhoux, LaureUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mazoyer, SylvieUNSPECIFIEDorcid.org/0000-0002-2135-0160UNSPECIFIED
Van Heetvelde, MattiasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Poppe, BruceUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
De Leeneer, KimUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Claes, Kathleen B. M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
de la Hoya, MiguelUNSPECIFIEDorcid.org/0000-0002-8113-1410UNSPECIFIED
Garcia-Barberan, VanesaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Caldes, TrinidadUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Perez Segura, PedroUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kiiski, Johanna I.UNSPECIFIEDorcid.org/0000-0002-4089-7209UNSPECIFIED
Aittomaeki, KristiinaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Khan, SofiaUNSPECIFIEDorcid.org/0000-0003-4185-8882UNSPECIFIED
Nevanlinna, HeliUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
van Asperen, Christi J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Vaszko, TiborUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kasler, MiklosUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Olah, EdithUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Balmana, JudithUNSPECIFIEDorcid.org/0000-0002-0762-6415UNSPECIFIED
Gutierrez-Enriquez, SaraUNSPECIFIEDorcid.org/0000-0002-1711-6101UNSPECIFIED
Diez, OrlandUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Teule, AlexUNSPECIFIEDorcid.org/0000-0003-0028-7200UNSPECIFIED
Izquierdo, AngelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Darder, EstherUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Brunet, JoanUNSPECIFIEDorcid.org/0000-0003-1945-3512UNSPECIFIED
Del Valle, JesusUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Feliubadalo, LidiaUNSPECIFIEDorcid.org/0000-0002-1736-0112UNSPECIFIED
Pujana, Miquel AngelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lazaro, ConxiUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Arason, AdalgeirUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Agnarsson, Bjarni A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Johannsson, Oskar Th.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Barkardottir, Rosa B.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Alducci, ElisaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Tognazzo, SilviaUNSPECIFIEDorcid.org/0000-0002-6260-1261UNSPECIFIED
Montagna, MarcoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Teixeira, Manuel R.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pinto, PedroUNSPECIFIEDorcid.org/0000-0001-6289-5792UNSPECIFIED
Spurdle, Amanda B.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Holland, HeleneUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lee, Jong WonUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lee, Min HyukUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lee, JihyounUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kim, Sung-WonUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kang, EunyoungUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kim, ZisunUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sharma, PriyankaUNSPECIFIEDorcid.org/0000-0001-8592-2239UNSPECIFIED
Rebbeck, Timothy R.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Vijai, JosephUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Robson, MarkUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lincoln, AnneUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Musinsky, JacobUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gaddam, PragnaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Tan, Yen Y.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Berger, AndreasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Singer, Christian F.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Loud, Jennifer T.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Greene, Mark H.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mulligan, Anna MarieUNSPECIFIEDorcid.org/0000-0002-7239-5297UNSPECIFIED
Glendon, GordUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Andrulis, Irene L.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Toland, Amanda EwartUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Senter, LeighaUNSPECIFIEDorcid.org/0000-0001-9270-8847UNSPECIFIED
Bojesen, AndersUNSPECIFIEDorcid.org/0000-0003-4289-8595UNSPECIFIED
Nielsen, Henriette RoedUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Skytte, Anne-BineUNSPECIFIEDorcid.org/0000-0002-0067-9557UNSPECIFIED
Sunde, LoneUNSPECIFIEDorcid.org/0000-0002-8479-165XUNSPECIFIED
Jensen, Uffe BirkUNSPECIFIEDorcid.org/0000-0002-6205-6355UNSPECIFIED
Pedersen, Inge SokildeUNSPECIFIEDorcid.org/0000-0002-9902-8040UNSPECIFIED
Krogh, LotteUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kruse, Torben A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Caligo, Maria A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Yoon, Sook-YeeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Teo, Soo-HwangUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
von Wachenfeldt, AnnaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Huo, DezhengUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Nielsen, Sarah M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Olopade, Olufunmilayo I.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Nathanson, Katherine L.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Domchek, Susan M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lorenchick, ChristaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Jankowitz, Rachel C.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Campbell, IanUNSPECIFIEDorcid.org/0000-0002-7773-4155UNSPECIFIED
James, PaulUNSPECIFIEDorcid.org/0000-0002-4361-4657UNSPECIFIED
Mitchell, GillianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Orr, NickUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Park, Sue KyungUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Thomassen, MadsUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Offit, KennethUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Couch, Fergus J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Simard, JacquesUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Easton, Douglas F.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Chenevix-Trench, GeorgiaUNSPECIFIEDorcid.org/0000-0002-1878-2587UNSPECIFIED
Schmutzler, Rita K.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Antoniou, Antonis C.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ottini, LauraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-225079
DOI: 10.1200/JCO.2016.69.4935
Journal or Publication Title: J. Clin. Oncol.
Volume: 35
Number: 20
Page Range: S. 2240 - 2257
Date: 2017
Publisher: AMER SOC CLINICAL ONCOLOGY
Place of Publication: ALEXANDRIA
ISSN: 1527-7755
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
GENOME-WIDE ASSOCIATION; SUSCEPTIBILITY LOCI; FUNCTIONAL VARIANTS; GENETIC-VARIANTS; IDENTIFICATIONMultiple languages
OncologyMultiple languages
Refereed: Yes
URI: http://kups.ub.uni-koeln.de/id/eprint/22507

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