Schennach, Rebecca, Obermeier, Michael, Seemueller, Florian, Jaeger, Markus, Schmauss, Max, Laux, Gerd, Pfeiffer, Herbert, Naber, Dieter, Schmidt, Lutz G., Gaebel, Wolfgang, Klosterkoeter, Joachim, Heuser, Isabella, Maier, Wolfgang, Lemke, Matthias R., Ruether, Eckart, Klingberg, Stefan ORCID: 0000-0001-8081-7181, Gastpar, Markus, Spellmann, Ilja, Musil, Richard ORCID: 0000-0002-0792-8413, Moeller, Hans-Jurgen and Riedel, Michael (2017). Add-on Antidepressants in the Naturalistic Treatment of - Schizophrenia Spectrum Disorder - When, Who, and How? Pharmacopsychiatry, 50 (4). S. 136 - 145. STUTTGART: GEORG THIEME VERLAG KG. ISSN 1439-0795

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Abstract

Introduction The aim of this study was to evaluate antidepressant add-on treatment within the acute treatment of schizophrenia spectrum disorder patients. Methods Antidepressant add-on was evaluated in 365 patients within a naturalistic multicenter study. Patients with/without antidepressant add-on were compared regarding clinical and treatment-related variables, response and remission, and remission of depressive and negative symptoms. The efficacy of antidepressant add-on treatment was furthermore analyzed applying marginal structure models. Results Twenty-three percent of the patients received antidepressant add-on for a mean duration of 50.28 (33.42) days. Patients with the diagnosis of a schizoaffective disorder, multiple illness episodes, and a longer duration of their illness as well as those with significantly fewer baseline positive symptoms, more negative and depressive symptoms, more side effects, and less subjective well-being were augmented with antidepressants. At discharge no significant effect of antidepressant add-on treatment was observed in terms of a 25 % improvement (p = 0.2623), a 50 % improvement (p = 0.3946), remission (p = 0.0552), or remission of depressive (p = 0.6336) and negative symptoms (p = 0.8756). Also, when analyzing marginal structure models considering the diagnostic subgroups, no significant effect was found. Discussion Add-on with antidepressants is common. A final recommendation in terms of this strategy's efficacy cannot be given.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Schennach, RebeccaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Obermeier, MichaelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Seemueller, FlorianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Jaeger, MarkusUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schmauss, MaxUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Laux, GerdUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pfeiffer, HerbertUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Naber, DieterUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schmidt, Lutz G.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gaebel, WolfgangUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Klosterkoeter, JoachimUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Heuser, IsabellaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Maier, WolfgangUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lemke, Matthias R.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ruether, EckartUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Klingberg, StefanUNSPECIFIEDorcid.org/0000-0001-8081-7181UNSPECIFIED
Gastpar, MarkusUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Spellmann, IljaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Musil, RichardUNSPECIFIEDorcid.org/0000-0002-0792-8413UNSPECIFIED
Moeller, Hans-JurgenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Riedel, MichaelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-225490
DOI: 10.1055/s-0043-106436
Journal or Publication Title: Pharmacopsychiatry
Volume: 50
Number: 4
Page Range: S. 136 - 145
Date: 2017
Publisher: GEORG THIEME VERLAG KG
Place of Publication: STUTTGART
ISSN: 1439-0795
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
MARGINAL STRUCTURAL MODELS; NEGATIVE SYMPTOMS; PSYCHIATRIC-TREATMENT; TREATMENT RESPONSE; DEPRESSION; POLYPHARMACY; EPISODE; METAANALYSIS; MONOTHERAPY; PATTERNSMultiple languages
Pharmacology & Pharmacy; PsychiatryMultiple languages
Refereed: Yes
URI: http://kups.ub.uni-koeln.de/id/eprint/22549

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