Universität zu Köln

Safi, Ali-Farid, Grandoch, Andrea, Nickenig, Hans-Joachim, Zoeller, Joachim E. and Kreppel, Matthias (2017). The importance of lymph node ratio for locoregional recurrence of squamous cell carcinoma of the tongue. J. Cranio-MaxilloFac. Surg., 45 (7). S. 1058 - 1062. EDINBURGH: CHURCHILL LIVINGSTONE. ISSN 1878-4119

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Abstract

Introduction: Locoregional recurrence plays a key role in treatment failure of patients with squamous cell carcinoma of the tongue. In a large amount of studies lymph node ratio could be demonstrated as a promising parameter to stratify risk of patients with oral cavity cancer. However data on the influence of lymph node ratio on locoregional recurrence of tongue squamous cell carcinoma is very rare. Material and methods: Retrospective chart review of 130 patients with treatment naive squamous cell carcinoma of the tongue. Exclusion criteria were neoadjuvant chemoradiotherapy, perioperative death, N3 disease, unresectable disease, synchronous malignancy, follow up < 3 months. Contingency tables and chi(2)-test were performed to analyze associations between clinicopathological features and recurrence. All statistic were 2-sided and a p-value < 0.05 was considered as significant. Multivariate analysis was performed using binary logistic regression analysis. A cut off value of 6% for lymph node ratio was applied. Results: Significant correlations were found between locoregional recurrence and pathologic N-Classification (< 0.001), UICC stage (< 0.001), perineural invasion (p = 0.025), grading (p = 0.001), number of resected lymph nodes (p = 0.007) and lymph node ratio (p < 0.001). Multivariate analysis indicated lymph node ratio as solely independent risk factor for locoregional recurrence. Conclusions: Lymph node ratio may be an useful parameter to stratify risk of locoregional recurrence of patients with squamous cell carcinoma of the tongue. Thus lymph node ratio might help to improve diagnosis and therapy of affected patients. (C) 2017 European Association for Cranio-Maxillo-Facial Surgery. Published by Elsevier Ltd. All rights reserved.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Safi, Ali-Farid UNSPECIFIED UNSPECIFIED UNSPECIFIED Grandoch, Andrea UNSPECIFIED UNSPECIFIED UNSPECIFIED Nickenig, Hans-Joachim UNSPECIFIED UNSPECIFIED UNSPECIFIED Zoeller, Joachim E. UNSPECIFIED UNSPECIFIED UNSPECIFIED Kreppel, Matthias UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-226138
DOI:	10.1016/j.jcms.2017.04.008
Journal or Publication Title:	J. Cranio-MaxilloFac. Surg.
Volume:	45
Number:	7
Page Range:	S. 1058 - 1062
Date:	2017
Publisher:	CHURCHILL LIVINGSTONE
Place of Publication:	EDINBURGH
ISSN:	1878-4119
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language Dentistry, Oral Surgery & Medicine; Surgery Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/22613