Universität zu Köln

Zagorski, Marcin ORCID: 0000-0001-7896-7762, Tabata, Yoji, Brandenberg, Nathalie, Lutolf, Matthias P., Tkacik, Gasper ORCID: 0000-0002-6699-1455, Bollenbach, Tobias ORCID: 0000-0003-4398-476X, Briscoe, James ORCID: 0000-0002-1020-5240 and Kicheva, Anna (2017). Decoding of position in the developing neural tube from antiparallel morphogen gradients. Science, 356 (6345). S. 1379 - 1383. WASHINGTON: AMER ASSOC ADVANCEMENT SCIENCE. ISSN 1095-9203

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Abstract

Like many developing tissues, the vertebrate neural tube is patterned by antiparallel morphogen gradients. To understand how these inputs are interpreted, we measured morphogen signaling and target gene expression in mouse embryos and chick ex vivo assays. From these data, we derived and validated a characteristic decoding map that relates morphogen input to the positional identity of neural progenitors. Analysis of the observed responses indicates that the underlying interpretation strategy minimizes patterning errors in response to the joint input of noisy opposing gradients. We reverse-engineered a transcriptional network that provides a mechanistic basis for the observed cell fate decisions and accounts for the precision and dynamics of pattern formation. Together, our data link opposing gradient dynamics in a growing tissue to precise pattern formation.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Zagorski, Marcin UNSPECIFIED orcid.org/0000-0001-7896-7762 UNSPECIFIED Tabata, Yoji UNSPECIFIED UNSPECIFIED UNSPECIFIED Brandenberg, Nathalie UNSPECIFIED UNSPECIFIED UNSPECIFIED Lutolf, Matthias P. UNSPECIFIED UNSPECIFIED UNSPECIFIED Tkacik, Gasper UNSPECIFIED orcid.org/0000-0002-6699-1455 UNSPECIFIED Bollenbach, Tobias UNSPECIFIED orcid.org/0000-0003-4398-476X UNSPECIFIED Briscoe, James UNSPECIFIED orcid.org/0000-0002-1020-5240 UNSPECIFIED Kicheva, Anna UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-227166
DOI:	10.1126/science.aam5887
Journal or Publication Title:	Science
Volume:	356
Number:	6345
Page Range:	S. 1379 - 1383
Date:	2017
Publisher:	AMER ASSOC ADVANCEMENT SCIENCE
Place of Publication:	WASHINGTON
ISSN:	1095-9203
Language:	English
Faculty:	Faculty of Mathematics and Natural Sciences
Divisions:	Faculty of Mathematics and Natural Sciences > Department of Physics > Institut für Biologische Physik
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language SONIC HEDGEHOG; REPRESSOR ACTIVITY; MOTOR-NEURON; INFORMATION; PRECISION; NOTOCHORD; DESIGN; GENES Multiple languages Multidisciplinary Sciences Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/22716