Universität zu Köln

Filss, Christian P., Cicone, Francesco ORCID: 0000-0003-4664-1965, Shah, Nadim Jon, Galldiks, Norbert ORCID: 0000-0002-2485-1796 and Langen, Karl-Josef ORCID: 0000-0003-1101-5075 (2017). Amino acid PET and MR perfusion imaging in brain tumours. Clin. Transl. Imaging, 5 (3). S. 209 - 224. MILAN: SPRINGER-VERLAG ITALIA SRL. ISSN 2281-7565

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Abstract

Purpose Despite the excellent capacity of the conventional MRI to image brain tumours, problems remain in answering a number of critical diagnostic questions. To overcome these diagnostic shortcomings, PET using radiolabeled amino acids and perfusion-weighted imaging (PWI) are currently under clinical evaluation. The role of amino acid PET and PWI in different diagnostic challenges in brain tumours is controversial. Methods Based on the literature and experience of our centres in correlative imaging with PWI and PET using O-(2-[F-18]fluoroethyl)-l-tyrosine or 3,4-dihydroxy-6-[F-18]-fluoro-l-phenylalanine, the current role and shortcomings of amino acid PET and PWI in different diagnostic challenges in brain tumours are reviewed. Literature searches were performed on PubMed, and additional literature was retrieved from the reference lists of identified articles. In particular, all studies in which amino acid PET was directly compared with PWI were included. Results PWI is more readily available, but requires substantial expertise and is more sensitive to artifacts than amino acid PET. At initial diagnosis, PWI and amino acid PET can help to define a site for biopsy but amino acid PET appears to be more powerful to define the tumor extent. Both methods are helpful to differentiate progression or recurrence from unspecific posttherapeutic changes. Assessment of therapeutic efficacy can be achieved especially with amino acid PET, while the data with PWI are sparse. Conclusion Both PWI and amino acid PET add valuable diagnostic information to the conventional MRI in the assessment of patients with brain tumours, but further studies are necessary to explore the complementary nature of these two methods.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Filss, Christian P. UNSPECIFIED UNSPECIFIED UNSPECIFIED Cicone, Francesco UNSPECIFIED orcid.org/0000-0003-4664-1965 UNSPECIFIED Shah, Nadim Jon UNSPECIFIED UNSPECIFIED UNSPECIFIED Galldiks, Norbert UNSPECIFIED orcid.org/0000-0002-2485-1796 UNSPECIFIED Langen, Karl-Josef UNSPECIFIED orcid.org/0000-0003-1101-5075 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-229610
DOI:	10.1007/s40336-017-0225-z
Journal or Publication Title:	Clin. Transl. Imaging
Volume:	5
Number:	3
Page Range:	S. 209 - 224
Date:	2017
Publisher:	SPRINGER-VERLAG ITALIA SRL
Place of Publication:	MILAN
ISSN:	2281-7565
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language POSITRON-EMISSION-TOMOGRAPHY; CEREBRAL BLOOD-VOLUME; HIGH-GRADE GLIOMAS; RECURRENT MALIGNANT GLIOMA; DYNAMIC F-18-FET PET; APPARENT DIFFUSION-COEFFICIENT; CONTRAST-ENHANCED MRI; F-DOPA PET; C-11-METHIONINE PET; O-(2-F-18-FLUOROETHYL)-L-TYROSINE PET Multiple languages Radiology, Nuclear Medicine & Medical Imaging Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/22961