Universität zu Köln

Heiligenhaus, Arnd, Kasper, Maren and Grajewski, Rafael (2017). HLA-B27 Positive Acute Anterior Uveitis - A Translational Perspective. Klinische Monatsblat. Augenheilkunde, 234 (5). S. 652 - 657. STUTTGART: GEORG THIEME VERLAG KG. ISSN 1439-3999

Full text not available from this repository.

Abstract

Background HLA-B27 positive acute anterior uveitis is the most common type of uveitis, and it is an autoimmune disease that can be triggered by infections. The precise mechanism of the interaction between involved microbes (mostly gram negative bacteria) and the host immune system is not clear. The disease probably results from an imbalance between pro-and anti-inflammatory components. Project description This article gives a compact overview about the current knowledge of the clinic and the etiopathogenesis of acute anterior uveitis as a basis for future research approaches. The goal of the current research is to classify the cellular and molecular pathogenetic factors in acute anterior uveitis. In this regard, a project on uveitis within the clinical research unit FOR 2240 (Lymph) Angiogenesis and Cellular Immunity in Inflammatory Diseases of the Eye, examines the hypothesis that dysregulation of regulatory cell populations and anti-inflammatory cytokines, such as interleukin-10 (IL-10), might contribute to the development of ocular autoimmunity following infections. The goal is to establish new markers for individual susceptibility in the risk group of the HLA-B27 positive population, because only about 1% of the HLA-B27 positive population will eventually develop acute anterior uveitis. Conclusions Translational research approaches to identify predisposed risk groups from the HLA-B27 population could improve patient care both on a prophylactic and a therapeutic level.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Heiligenhaus, Arnd UNSPECIFIED UNSPECIFIED UNSPECIFIED Kasper, Maren UNSPECIFIED UNSPECIFIED UNSPECIFIED Grajewski, Rafael UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-232030
DOI:	10.1055/s-0043-105139
Journal or Publication Title:	Klinische Monatsblat. Augenheilkunde
Volume:	234
Number:	5
Page Range:	S. 652 - 657
Date:	2017
Publisher:	GEORG THIEME VERLAG KG
Place of Publication:	STUTTGART
ISSN:	1439-3999
Language:	German
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language ANKYLOSING-SPONDYLITIS; NONINFECTIOUS UVEITIS; T-CELLS; ADALIMUMAB; CHLAMYDIA; ARTHRITIS; POPULATION; FREQUENCY; SUBTYPES; DISEASE Multiple languages Ophthalmology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/23203