Universität zu Köln

Bosch, Jacobus J. and Heindl, Ludwig M. (2017). Novel Adjuvant Therapy for Ocular Melanoma. Klinische Monatsblat. Augenheilkunde, 234 (5). S. 670 - 674. STUTTGART: GEORG THIEME VERLAG KG. ISSN 1439-3999

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Abstract

Background Malignant melanoma is the most common cancer of the eye in adults that originates either in the intra-ocular uveal tract or extra-ocular conjunctiva. Although the primary tumor can be treated successfully, no effective therapy for both metastatic conjunctival and uveal melanoma currently exits. Tumor-associated lymphangiogenesis and immune cell infiltration play a pivotal role in the development and therapeutic targeting of metastases. Project description Here, we provide an overview of current translational research on lymphangiogenesis and its therapeutic inhibition as well as modulation of immune cell infiltration by passive and active immunotherapy inmelanoma of the eye. Specifically, our previous and ongoing work on lymphangiogenesis and immune cells in ocular melanoma within the clinical research unit FOR 2240 (Lymph) Angiogenesis and Cellular Immunity in Inflammatory Diseases of the Eye is summarized. Conclusions Translational research on the modulation of tumor-associated lymphangiogenesis and immune cell infiltration could provide novel targets for adjuvant therapy in melanoma of the eye.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Bosch, Jacobus J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Heindl, Ludwig M. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-232060
DOI:	10.1055/s-0043-107807
Journal or Publication Title:	Klinische Monatsblat. Augenheilkunde
Volume:	234
Number:	5
Page Range:	S. 670 - 674
Date:	2017
Publisher:	GEORG THIEME VERLAG KG
Place of Publication:	STUTTGART
ISSN:	1439-3999
Language:	German
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language TUMOR-ASSOCIATED LYMPHANGIOGENESIS; CILIARY-BODY-MELANOMAS; UVEAL MELANOMA; CONJUNCTIVAL MELANOMA; EXTRAOCULAR-EXTENSION; HUMAN SCLERA; MALIGNANT MELANOMAS; LYMPHATIC MARKERS; FUTURE-DIRECTIONS; IMMUNE PRIVILEGE Multiple languages Ophthalmology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/23206