Universität zu Köln

Lin, Guangzhong, Zhang, Liang, Han, Zhifu, Yang, Xinru, Liu, Weijia, Li, Ertong, Chang, Junbiao, Qi, Yijun, Shpak, Elena D. and Chai, Jijie (2017). A receptor-like protein acts as a specificity switch for the regulation of stomatal development. Genes Dev., 31 (9). S. 927 - 939. COLD SPRING HARBOR: COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT. ISSN 1549-5477

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Abstract

Stomata are microscopic openings that allow for the exchange of gases between plants and the environment. In Arabidopsis, stomatal patterning is specified by the ERECTA family (ERf) receptor kinases (RKs), the receptor-like protein (RLP) TOO MANY MOUTHS (TMM), and EPIDERMAL PATTERNING FACTOR (EPF) peptides. Here we show that TMM and ER or ER-LIKE1 (ERL1) form constitutive complexes, which recognize EPF1 and EPF2, but the single ERfs do not. TMM interaction with ERL1 creates a binding pocket for recognition of EPF1 and EPF2, indicating that the constitutive TMM-ERf complexes function as the receptors of EPF1 and EPF2. EPFL9 competes with EPF1 and EPF2 for binding to the ERf-TMM complex. EPFL4 and EPFL6, however, are recognized by the single ERfs without the requirement of TMM. In contrast to EPF1,2, the interaction of EPFL4,6 with an ERf is greatly reduced in the presence of TMM. Taken together, our data demonstrate that TMM dictates the specificity of ERfs for the perception of different EPFs, thus functioning as a specificity switch for the regulation of the activities of ERfs.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Lin, Guangzhong UNSPECIFIED UNSPECIFIED UNSPECIFIED Zhang, Liang UNSPECIFIED UNSPECIFIED UNSPECIFIED Han, Zhifu UNSPECIFIED UNSPECIFIED UNSPECIFIED Yang, Xinru UNSPECIFIED UNSPECIFIED UNSPECIFIED Liu, Weijia UNSPECIFIED UNSPECIFIED UNSPECIFIED Li, Ertong UNSPECIFIED UNSPECIFIED UNSPECIFIED Chang, Junbiao UNSPECIFIED UNSPECIFIED UNSPECIFIED Qi, Yijun UNSPECIFIED UNSPECIFIED UNSPECIFIED Shpak, Elena D. UNSPECIFIED UNSPECIFIED UNSPECIFIED Chai, Jijie UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-233198
DOI:	10.1101/gad.297580.117
Journal or Publication Title:	Genes Dev.
Volume:	31
Number:	9
Page Range:	S. 927 - 939
Date:	2017
Publisher:	COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT
Place of Publication:	COLD SPRING HARBOR
ISSN:	1549-5477
Language:	English
Faculty:	Faculty of Mathematics and Natural Sciences
Divisions:	Faculty of Mathematics and Natural Sciences > Department of Chemistry > Institute of Biochemistry
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language SECRETORY PEPTIDE; ARABIDOPSIS; DENSITY; KINASES; MOUTHS; TOO; REVEALS; PATTERN; SHAPE Multiple languages Cell Biology; Developmental Biology; Genetics & Heredity Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/23319