Hartings, Jed A., Shuttleworth, C. William, Kirov, Sergei A., Ayata, Cenk, Hinzman, Jason M., Foreman, Brandon ORCID: 0000-0002-5418-674X, Andrew, R. David, Boutelle, Martyn G., Brennan, K. C., Carlson, Andrew P., Dahlem, Markus A., Drenckhahn, Christoph, Dohmen, Christian, Fabricius, Martin, Farkas, Eszter ORCID: 0000-0002-8478-9664, Feuerstein, Delphine, Graf, Rudolf, Helbok, Raimund, Lauritzen, Martin, Major, Sebastian ORCID: 0000-0003-0970-1308, Oliveira-Ferreira, Ana I., Richter, Frank, Rosenthal, Eric S., Sakowitz, Oliver W., Sanchez-Porras, Renan ORCID: 0000-0002-9084-8114, Santos, Edgar ORCID: 0000-0002-8976-5549, Scholl, Michael, Strong, Anthony J., Urbach, Anja, Westover, M. Brandon, Winkler, Maren K. L., Witte, Otto W., Woitzik, Johannes and Dreier, Jens P. (2017). The continuum of spreading depolarizations in acute cortical lesion development: Examining Le(a)over-tilde-$o's legacy. J. Cereb. Blood Flow Metab., 37 (5). S. 1571 - 1595. THOUSAND OAKS: SAGE PUBLICATIONS INC. ISSN 1559-7016

Full text not available from this repository.

Abstract

A modern understanding of how cerebral cortical lesions develop after acute brain injury is based on Aristides Le (a) over tilde $o's historic discoveries of spreading depression and asphyxial/anoxic depolarization. Treated as separate entities for decades, we now appreciate that these events define a continuum of spreading mass depolarizations, a concept that is central to understanding their pathologic effects. Within minutes of acute severe ischemia, the onset of persistent depolarization triggers the breakdown of ion homeostasis and development of cytotoxic edema. These persistent changes are diagnosed as diffusion restriction in magnetic resonance imaging and define the ischemic core. In delayed lesion growth, transient spreading depolarizations arise spontaneously in the ischemic penumbra and induce further persistent depolarization and excitotoxic damage, progressively expanding the ischemic core. The causal role of these waves in lesion development has been proven by real-time monitoring of electrophysiology, blood flow, and cytotoxic edema. The spreading depolarization continuum further applies to other models of acute cortical lesions, suggesting that it is a universal principle of cortical lesion development. These pathophysiologic concepts establish a working hypothesis for translation to human disease, where complex patterns of depolarizations are observed in acute brain injury and appear to mediate and signal ongoing secondary damage.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Hartings, Jed A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Shuttleworth, C. WilliamUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kirov, Sergei A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ayata, CenkUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hinzman, Jason M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Foreman, BrandonUNSPECIFIEDorcid.org/0000-0002-5418-674XUNSPECIFIED
Andrew, R. DavidUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Boutelle, Martyn G.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Brennan, K. C.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Carlson, Andrew P.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Dahlem, Markus A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Drenckhahn, ChristophUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Dohmen, ChristianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Fabricius, MartinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Farkas, EszterUNSPECIFIEDorcid.org/0000-0002-8478-9664UNSPECIFIED
Feuerstein, DelphineUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Graf, RudolfUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Helbok, RaimundUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lauritzen, MartinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Major, SebastianUNSPECIFIEDorcid.org/0000-0003-0970-1308UNSPECIFIED
Oliveira-Ferreira, Ana I.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Richter, FrankUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rosenthal, Eric S.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sakowitz, Oliver W.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sanchez-Porras, RenanUNSPECIFIEDorcid.org/0000-0002-9084-8114UNSPECIFIED
Santos, EdgarUNSPECIFIEDorcid.org/0000-0002-8976-5549UNSPECIFIED
Scholl, MichaelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Strong, Anthony J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Urbach, AnjaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Westover, M. BrandonUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Winkler, Maren K. L.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Witte, Otto W.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Woitzik, JohannesUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Dreier, Jens P.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-233318
DOI: 10.1177/0271678X16654495
Journal or Publication Title: J. Cereb. Blood Flow Metab.
Volume: 37
Number: 5
Page Range: S. 1571 - 1595
Date: 2017
Publisher: SAGE PUBLICATIONS INC
Place of Publication: THOUSAND OAKS
ISSN: 1559-7016
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
MIDDLE CEREBRAL-ARTERY; EXTRACELLULAR POTASSIUM CONCENTRATION; APPARENT DIFFUSION-COEFFICIENT; TRAUMATIC BRAIN-INJURY; ISCHEMIC NEUROLOGICAL DEFICITS; ACUTE SUBDURAL-HEMATOMA; DIRECT-CURRENT SHIFTS; BLOOD-FLOW; ANOXIC DEPOLARIZATION; PERIINFARCT DEPOLARIZATIONSMultiple languages
Endocrinology & Metabolism; Hematology; NeurosciencesMultiple languages
Refereed: Yes
URI: http://kups.ub.uni-koeln.de/id/eprint/23331

Downloads

Downloads per month over past year

Altmetric

Export

Actions (login required)

View Item View Item