Habbig, Sandra, Volland, Ruth, Krupka, Kai, Querfeld, Uwe, Dello Strologo, Luca, Noyan, Aytul, Yalcinkaya, Fatos, Topaloglu, Rezan, Webb, Nicholas J. A., Kemper, Markus J., Pape, Lars, Bald, Martin, Kranz, Birgitta, Taylan, Christina, Hoecker, Britta, Toenshoff, Burkhard and Weber, Lutz T. (2017). Dyslipidemia after pediatric renal transplantation-The impact of immunosuppressive regimens. Pediatr. Transplant., 21 (3). HOBOKEN: WILEY. ISSN 1399-3046

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Abstract

Dyslipidemia contributes to cardiovascular morbidity and mortality in pediatric transplant recipients. Data on prevalence and risk factors in pediatric cohorts are, however, scarce. We therefore determined the prevalence of dyslipidemia in 386 pediatric renal transplant recipients enrolled in the CERTAIN registry. Data were obtained before and during the first year after RTx to analyze possible non-modifiable and modifiable risk factors. The prevalence of dyslipidemia was 95% before engraftment and 88% at 1year post-transplant. Low estimated glomerular filtration rate at 1year post-transplant was associated with elevated serum triglyceride levels. The use of TAC and of MPA was associated with significantly lower concentrations of all lipid parameters compared to regimens containing CsA and mTORi. Immunosuppressive regimens consisting of CsA, MPA, and steroids as well as of CsA, mTORi, and steroids were associated with a three- and 25-fold (P<.001) increased risk of having more than one pathologic lipid parameter as compared to the use of TAC, MPA, and steroids. Thus, amelioration of the cardiovascular risk profile after pediatric RTx may be attained by adaption of the immunosuppressive regimen according to the individual risk profile.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Habbig, SandraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Volland, RuthUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Krupka, KaiUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Querfeld, UweUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Dello Strologo, LucaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Noyan, AytulUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Yalcinkaya, FatosUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Topaloglu, RezanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Webb, Nicholas J. A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kemper, Markus J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pape, LarsUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bald, MartinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kranz, BirgittaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Taylan, ChristinaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hoecker, BrittaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Toenshoff, BurkhardUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Weber, Lutz T.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-233615
DOI: 10.1111/petr.12914
Journal or Publication Title: Pediatr. Transplant.
Volume: 21
Number: 3
Date: 2017
Publisher: WILEY
Place of Publication: HOBOKEN
ISSN: 1399-3046
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
SOLID-ORGAN TRANSPLANTATION; CLINICAL-PRACTICE GUIDELINE; CARDIOVASCULAR RISK-FACTORS; CHRONIC KIDNEY-DISEASE; YOUNG-ADULTS; PATHOBIOLOGICAL DETERMINANTS; LIPOPROTEIN METABOLISM; LIPID MANAGEMENT; BLOOD-PRESSURE; CHILDRENMultiple languages
Pediatrics; TransplantationMultiple languages
Refereed: Yes
URI: http://kups.ub.uni-koeln.de/id/eprint/23361

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