Universität zu Köln

Freytag, Virginie, Carrillo-Roa, Tania ORCID: 0000-0001-6025-7017, Milnik, Annette ORCID: 0000-0002-3933-3289, Mann, Philipp G. Sa, Vukojevic, Vanja ORCID: 0000-0001-5303-9492, Coynel, David ORCID: 0000-0001-5028-5807, Demougin, Philippe, Egli, Tobias ORCID: 0000-0001-7499-8991, Gschwind, Leo, Jessen, Frank, Loos, Eva, Maier, Wolfgang, Riedel-Heller, Steffi G., Scherer, Martin, Vogler, Christian, Wagner, Michael ORCID: 0000-0003-2589-6440, Binder, Elisabeth B., de Quervain, Dominique J. -F. and Papassotiropoulos, Andreas ORCID: 0000-0002-2210-9651 (2017). A peripheral epigenetic signature of immune system genes is linked to neocortical thickness and memory. Nat. Commun., 8. S. 1 - 13. LONDON: NATURE PUBLISHING GROUP. ISSN 2041-1723

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Abstract

Increasing age is tightly linked to decreased thickness of the human neocortex. The biological mechanisms that mediate this effect are hitherto unknown. The DNA methylome, as part of the epigenome, contributes significantly to age-related phenotypic changes. Here, we identify an epigenetic signature that is associated with cortical thickness (P = 3.86 x 10(-8)) and memory performance in 533 healthy young adults. The epigenetic effect on cortical thickness was replicated in a sample comprising 596 participants with major depressive disorder and healthy controls. The epigenetic signature mediates partially the effect of age on cortical thickness (P < 0.001). A multilocus genetic score reflecting genetic variability of this signature is associated with memory performance (P = 0.0003) in 3,346 young and elderly healthy adults. The genomic location of the contributing methylation sites points to the involvement of specific immune system genes. The decomposition of blood methylome-wide patterns bears considerable potential for the study of brain-related traits.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Freytag, Virginie UNSPECIFIED UNSPECIFIED UNSPECIFIED Carrillo-Roa, Tania UNSPECIFIED orcid.org/0000-0001-6025-7017 UNSPECIFIED Milnik, Annette UNSPECIFIED orcid.org/0000-0002-3933-3289 UNSPECIFIED Mann, Philipp G. Sa UNSPECIFIED UNSPECIFIED UNSPECIFIED Vukojevic, Vanja UNSPECIFIED orcid.org/0000-0001-5303-9492 UNSPECIFIED Coynel, David UNSPECIFIED orcid.org/0000-0001-5028-5807 UNSPECIFIED Demougin, Philippe UNSPECIFIED UNSPECIFIED UNSPECIFIED Egli, Tobias UNSPECIFIED orcid.org/0000-0001-7499-8991 UNSPECIFIED Gschwind, Leo UNSPECIFIED UNSPECIFIED UNSPECIFIED Jessen, Frank UNSPECIFIED UNSPECIFIED UNSPECIFIED Loos, Eva UNSPECIFIED UNSPECIFIED UNSPECIFIED Maier, Wolfgang UNSPECIFIED UNSPECIFIED UNSPECIFIED Riedel-Heller, Steffi G. UNSPECIFIED UNSPECIFIED UNSPECIFIED Scherer, Martin UNSPECIFIED UNSPECIFIED UNSPECIFIED Vogler, Christian UNSPECIFIED UNSPECIFIED UNSPECIFIED Wagner, Michael UNSPECIFIED orcid.org/0000-0003-2589-6440 UNSPECIFIED Binder, Elisabeth B. UNSPECIFIED UNSPECIFIED UNSPECIFIED de Quervain, Dominique J. -F. UNSPECIFIED UNSPECIFIED UNSPECIFIED Papassotiropoulos, Andreas UNSPECIFIED orcid.org/0000-0002-2210-9651 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-233680
DOI:	10.1038/ncomms15193
Journal or Publication Title:	Nat. Commun.
Volume:	8
Page Range:	S. 1 - 13
Date:	2017
Publisher:	NATURE PUBLISHING GROUP
Place of Publication:	LONDON
ISSN:	2041-1723
Language:	English
Faculty:	Faculty of Management, Economy and Social Sciences
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language INDEPENDENT COMPONENT ANALYSIS; SURFACE-BASED ANALYSIS; DNA METHYLATION AGE; CORTICAL THICKNESS; HUMAN BRAIN; WIDE ASSOCIATION; CEREBRAL-CORTEX; HIGH-THROUGHPUT; EXPRESSION; MICROARRAY Multiple languages Multidisciplinary Sciences Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/23368