Universität zu Köln

Ludewig, Andreas H., Gimond, Clotilde ORCID: 0000-0003-1708-4629, Judkins, Joshua C., Thornton, Staci, Pulido, Dania C., Micikas, Robert J., Doering, Frank, Antebi, Adam, Braendle, Christian ORCID: 0000-0003-0203-4581 and Schroeder, Frank C. (2017). Larval crowding accelerates C-elegans development and reduces lifespan. PLoS Genet., 13 (4). SAN FRANCISCO: PUBLIC LIBRARY SCIENCE. ISSN 1553-7404

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Abstract

Environmental conditions experienced during animal development are thought to have sustained impact on maturation and adult lifespan. Here we show that in the model organism C. elegans developmental rate and adult lifespan depend on larval population density, and that this effect is mediated by excreted small molecules. By using the time point of first egg laying as a marker for full maturity, we found that wildtype hermaphrodites raised under high density conditions developed significantly faster than animals raised in isolation. Population density-dependent acceleration of development (Pdda) was dramatically enhanced in fatty acid beta-oxidation mutants that are defective in the biosynthesis of ascarosides, small-molecule signals that induce developmental diapause. In contrast, Pdda is abolished by synthetic ascarosides and steroidal ligands of the nuclear hormone receptor DAF-12. We show that neither ascarosides nor any known steroid hormones are required for Pdda and that another chemical signal mediates this phenotype, in part via the nuclear hormone receptor NHR-8. Our results demonstrate that C. elegans development is regulated by a push-pull mechanism, based on two antagonistic chemical signals: chemosensation of ascarosides slows down development, whereas population-density dependent accumulation of a different chemical signal accelerates development. We further show that the effects of high larval population density persist through adulthood, as C. elegans larvae raised at high densities exhibit significantly reduced adult lifespan and respond differently to exogenous chemical signals compared to larvae raised at low densities, independent of density during adulthood. Our results demonstrate how inter-organismal signaling during development regulates reproductive maturation and longevity.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Ludewig, Andreas H. UNSPECIFIED UNSPECIFIED UNSPECIFIED Gimond, Clotilde UNSPECIFIED orcid.org/0000-0003-1708-4629 UNSPECIFIED Judkins, Joshua C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Thornton, Staci UNSPECIFIED UNSPECIFIED UNSPECIFIED Pulido, Dania C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Micikas, Robert J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Doering, Frank UNSPECIFIED UNSPECIFIED UNSPECIFIED Antebi, Adam UNSPECIFIED UNSPECIFIED UNSPECIFIED Braendle, Christian UNSPECIFIED orcid.org/0000-0003-0203-4581 UNSPECIFIED Schroeder, Frank C. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-234572
DOI:	10.1371/journal.pgen.1006717
Journal or Publication Title:	PLoS Genet.
Volume:	13
Number:	4
Date:	2017
Publisher:	PUBLIC LIBRARY SCIENCE
Place of Publication:	SAN FRANCISCO
ISSN:	1553-7404
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language SMALL-MOLECULE SIGNALS; METABOLOMICS REVEALS; DAUER FORMATION; PHEROMONE; RECEPTOR; LONGEVITY; BEHAVIOR; REPRODUCTION; METABOLISM; MECHANISM Multiple languages Genetics & Heredity Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/23457