Universität zu Köln

Ratheesh, A., Davey, C., Hetrick, S., Alvarez-Jimenez, M., Voutier, C., Bechdolf, A., McGorry, P. D., Scott, J., Berk, M. and Cotton, S. M. (2017). A systematic review and meta-analysis of prospective transition from major depression to bipolar disorder. Acta Psychiatr. Scand., 135 (4). S. 273 - 285. HOBOKEN: WILEY. ISSN 1600-0447

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Abstract

Objective: Some people with major depressive disorder (MDD) may be at a pre-onset stage for bipolar disorder (BD), where early identification or prevention efforts may be feasible. We aimed to identify rates and characteristics predictive of transition to BD in prospective follow-up studies of people with MDD. Methods: Using a systematic search strategy, we identified studies with a diagnostic ascertainment of MDD and BD of an adequate standard, and where the minimum length of follow-up was 6 months. We examined the incidence and point prevalence of BD and the pooled odds ratios (OR) for baseline predictors. Results: From 5554 unique publications, 56 were included. Nearly a quarter of adults (22.5%) and adolescents with MDD followed up for a mean length of 12-18 years developed BD, with the greatest risk of transition being in the first 5 years. The meta-analysis identified that transition from MDD to BD was predicted by family history of BD (OR = 2.89, 95% CI: 2.01-4.14, N = 7), earlier age of onset of depression (g = -0.33, SE = 0.05, N = 6) and presence of psychotic symptoms (OR = 4.76, 95% CI: 1.79-12.66, N = 5). Conclusions: Participants with the identified risk factors merit closer observation and may benefit from prevention efforts, especially if outcomes broader than BD are considered.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Ratheesh, A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Davey, C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Hetrick, S. UNSPECIFIED UNSPECIFIED UNSPECIFIED Alvarez-Jimenez, M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Voutier, C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Bechdolf, A. UNSPECIFIED UNSPECIFIED UNSPECIFIED McGorry, P. D. UNSPECIFIED UNSPECIFIED UNSPECIFIED Scott, J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Berk, M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Cotton, S. M. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-235790
DOI:	10.1111/acps.12686
Journal or Publication Title:	Acta Psychiatr. Scand.
Volume:	135
Number:	4
Page Range:	S. 273 - 285
Date:	2017
Publisher:	WILEY
Place of Publication:	HOBOKEN
ISSN:	1600-0447
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language PROSPECTIVE FOLLOW-UP; DIAGNOSTIC CONVERSION; PSYCHOTIC DEPRESSION; MOOD DISORDERS; RISK-FACTORS; UNIPOLAR; PREDICTORS; ILLNESS; MANIA; ONSET Multiple languages Psychiatry Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/23579