Heilmann-Heimbach, Stefanie ORCID: 0000-0003-1057-465X, Herold, Christine, Hochfeld, Lara M., Hillmer, Axel M., Nyholt, Dale R., Hecker, Julian, Javed, Asif, Chew, Elaine G. Y., Pechlivanis, Sonali, Drichel, Dmitriy ORCID: 0000-0001-5978-3458, Heng, Xiu Ting, del Rosario, Ricardo C. -H., Fier, Heide L., Paus, Ralf, Rueedi, Rico, Galesloot, Tessel E., Moebus, Susanne, Anhalt, Thomas, Prabhakar, Shyam, Li, Rui, Kanoni, Stavroula ORCID: 0000-0002-1691-9615, Papanikolaou, George ORCID: 0000-0002-6755-3633, Kutalik, Zoltan, Deloukas, Panos, Philpott, Michael P., Waeber, Gerard ORCID: 0000-0003-4193-788X, Spector, Tim D., Vollenweider, Peter, Kiemeney, Lambertus A. L. M., Dedoussis, George, Richards, J. Brent, Nothnagel, Michael ORCID: 0000-0001-8305-7114, Martin, Nicholas G., Becker, Tim ORCID: 0000-0002-6573-1109, Hinds, David A. and Noethen, Markus M. (2017). Meta-analysis identifies novel risk loci and yields systematic insights into the biology of male-pattern baldness. Nat. Commun., 8. LONDON: NATURE PUBLISHING GROUP. ISSN 2041-1723

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Abstract

Male-pattern baldness (MPB) is a common and highly heritable trait characterized by androgen-dependent, progressive hair loss from the scalp. Here, we carry out the largest GWAS meta-analysis of MPB to date, comprising 10,846 early-onset cases and 11,672 controls from eight independent cohorts. We identify 63 MPB-associated loci (P<5 x 10(-8), METAL) of which 23 have not been reported previously. The 63 loci explain similar to 39% of the phenotypic variance in MPB and highlight several plausible candidate genes (FGF5, IRF4, DKK2) and pathways (melatonin signalling, adipogenesis) that are likely to be implicated in the key-pathophysiological features of MPB and may represent promising targets for the development of novel therapeutic options. The data provide molecular evidence that rather than being an isolated trait, MPB shares a substantial biological basis with numerous other human phenotypes and may deserve evaluation as an early prognostic marker, for example, for prostate cancer, sudden cardiac arrest and neurodegenerative disorders.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Heilmann-Heimbach, StefanieUNSPECIFIEDorcid.org/0000-0003-1057-465XUNSPECIFIED
Herold, ChristineUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hochfeld, Lara M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hillmer, Axel M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Nyholt, Dale R.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hecker, JulianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Javed, AsifUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Chew, Elaine G. Y.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pechlivanis, SonaliUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Drichel, DmitriyUNSPECIFIEDorcid.org/0000-0001-5978-3458UNSPECIFIED
Heng, Xiu TingUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
del Rosario, Ricardo C. -H.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Fier, Heide L.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Paus, RalfUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rueedi, RicoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Galesloot, Tessel E.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Moebus, SusanneUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Anhalt, ThomasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Prabhakar, ShyamUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Li, RuiUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kanoni, StavroulaUNSPECIFIEDorcid.org/0000-0002-1691-9615UNSPECIFIED
Papanikolaou, GeorgeUNSPECIFIEDorcid.org/0000-0002-6755-3633UNSPECIFIED
Kutalik, ZoltanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Deloukas, PanosUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Philpott, Michael P.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Waeber, GerardUNSPECIFIEDorcid.org/0000-0003-4193-788XUNSPECIFIED
Spector, Tim D.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Vollenweider, PeterUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kiemeney, Lambertus A. L. M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Dedoussis, GeorgeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Richards, J. BrentUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Nothnagel, MichaelUNSPECIFIEDorcid.org/0000-0001-8305-7114UNSPECIFIED
Martin, Nicholas G.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Becker, TimUNSPECIFIEDorcid.org/0000-0002-6573-1109UNSPECIFIED
Hinds, David A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Noethen, Markus M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-236755
DOI: 10.1038/ncomms14694
Journal or Publication Title: Nat. Commun.
Volume: 8
Date: 2017
Publisher: NATURE PUBLISHING GROUP
Place of Publication: LONDON
ISSN: 2041-1723
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
GENOME-WIDE ASSOCIATION; DERMAL PAPILLA CELLS; HAIR-GROWTH CYCLE; ANDROGENETIC ALOPECIA; SUSCEPTIBILITY VARIANTS; HUMAN PIGMENTATION; PROSTATE-CANCER; FOLLICLE; GENE; MELATONINMultiple languages
Multidisciplinary SciencesMultiple languages
Refereed: Yes
URI: http://kups.ub.uni-koeln.de/id/eprint/23675

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