Universität zu Köln

Mueller, Ralf, Papazoglou, Anna, Soos, Julien, Lundt, Andreas, Wormuth, Carola, Henseler, Christina, Ehninger, Dan, Broich, Karl and Weiergraeber, Marco (2017). Automatic Detection of Highly Organized Theta Oscillations in the Murine EEG. J. Vis. Exp. (121). CAMBRIDGE: JOURNAL OF VISUALIZED EXPERIMENTS. ISSN 1940-087X

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Abstract

Theta activity is generated in the septohippocampal system and can be recorded using deep intrahippocampal electrodes and implantable electroencephalography (EEG) radiotelemetry or tether system approaches. Pharmacologically, hippocampal theta is heterogeneous (see dualistic theory) and can be differentiated into type I and type II theta. These individual EEG subtypes are related to specific cognitive and behavioral states, such as arousal, exploration, learning and memory, higher integrative functions, etc. In neurodegenerative diseases such as Alzheimer's, structural and functional alterations of the septohippocampal system can result in impaired theta activity/oscillations. A standard quantitative analysis of the hippocampal EEG includes a Fast-Fourier-Transformation (FFT)-based frequency analysis. However, this procedure does not provide details about theta activity in general and highly-organized theta oscillations in particular. In order to obtain detailed information on highly-organized theta oscillations in the hippocampus, we have developed a new analytical approach. This approach allows for time-and cost-effective quantification of the duration of highly-organized theta oscillations and their frequency characteristics.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Mueller, Ralf UNSPECIFIED UNSPECIFIED UNSPECIFIED Papazoglou, Anna UNSPECIFIED UNSPECIFIED UNSPECIFIED Soos, Julien UNSPECIFIED UNSPECIFIED UNSPECIFIED Lundt, Andreas UNSPECIFIED UNSPECIFIED UNSPECIFIED Wormuth, Carola UNSPECIFIED UNSPECIFIED UNSPECIFIED Henseler, Christina UNSPECIFIED UNSPECIFIED UNSPECIFIED Ehninger, Dan UNSPECIFIED UNSPECIFIED UNSPECIFIED Broich, Karl UNSPECIFIED UNSPECIFIED UNSPECIFIED Weiergraeber, Marco UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-237707
DOI:	10.3791/55089
Journal or Publication Title:	J. Vis. Exp.
Number:	121
Date:	2017
Publisher:	JOURNAL OF VISUALIZED EXPERIMENTS
Place of Publication:	CAMBRIDGE
ISSN:	1940-087X
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language HIPPOCAMPAL THETA; MEDIAL SEPTUM; GABAERGIC NEURONS; RHYTHM HETEROGENEITY; ATROPINE; ACTIVATION; PATTERNS; URETHANE; NETWORK; MEMORY Multiple languages Multidisciplinary Sciences Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/23770