Schatton, Desiree, Pla-Martin, David, Marx, Marie-Charlotte, Hansen, Henriette, Mourier, Arnaud, Nemazanyy, Ivan, Pessia, Alberto ORCID: 0000-0001-8607-9191, Zentis, Peter, Corona, Teresa, Kondylis, Vangelis ORCID: 0000-0002-6970-8731, Barth, Esther, Schauss, Astrid C., Velagapudi, Vidya ORCID: 0000-0002-8261-7164 and Rugarli, Elena I. (2017). CLUH regulates mitochondrial metabolism by controlling translation and decay of target mRNAs. J. Cell Biol., 216 (3). S. 675 - 694. NEW YORK: ROCKEFELLER UNIV PRESS. ISSN 1540-8140

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Abstract

Mitochondria are essential organelles that host crucial metabolic pathways and produce adenosine triphosphate. The mitochondrial proteome is heterogeneous among tissues and can dynamically change in response to different metabolic conditions. Although the transcriptional programs that govern mitochondrial biogenesis and respiratory function are well known, posttranscriptional regulatory mechanisms remain unclear. In this study, we show that the cytosolic RNA-binding protein clustered mitochondria homologue (CLUH) regulates the expression of a mitochondrial protein network supporting key metabolic programs required under nutrient deprivation. CLUH exerts its function by controlling the stability and translation of target messenger RNAs. In the absence of Cluh, mitochondria are severely depleted of crucial enzymes involved in catabolic energy-converting pathways. CLUH preserves oxidative mitochondrial function and glucose homeostasis, thus preventing death at the fetal-neonatal transition. In the adult liver, CLUH ensures maximal respiration capacity and the metabolic response to starvation. Our results shed new light on the posttranscriptional mechanisms controlling the expression of mitochondrial proteins and suggest novel strategies to tailor mitochondrial function to physiological and pathological conditions.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Schatton, DesireeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pla-Martin, DavidUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Marx, Marie-CharlotteUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hansen, HenrietteUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mourier, ArnaudUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Nemazanyy, IvanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pessia, AlbertoUNSPECIFIEDorcid.org/0000-0001-8607-9191UNSPECIFIED
Zentis, PeterUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Corona, TeresaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kondylis, VangelisUNSPECIFIEDorcid.org/0000-0002-6970-8731UNSPECIFIED
Barth, EstherUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schauss, Astrid C.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Velagapudi, VidyaUNSPECIFIEDorcid.org/0000-0002-8261-7164UNSPECIFIED
Rugarli, Elena I.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-238497
DOI: 10.1083/jcb.201607019
Journal or Publication Title: J. Cell Biol.
Volume: 216
Number: 3
Page Range: S. 675 - 694
Date: 2017
Publisher: ROCKEFELLER UNIV PRESS
Place of Publication: NEW YORK
ISSN: 1540-8140
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
SACCHAROMYCES-CEREVISIAE; COMPUTATIONAL PLATFORM; IMAGE-ANALYSIS; PROTEIN; MOUSE; MICE; GENE; BIOGENESIS; INITIATION; PROTEOMICSMultiple languages
Cell BiologyMultiple languages
Refereed: Yes
URI: http://kups.ub.uni-koeln.de/id/eprint/23849

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