Universität zu Köln

Brueckl, W. M., Wirtz, R. M., Bertsch, T., Ficker, J. H. and Jung, A. (2017). Liquid Biopsy: Detection of Molecular Markers for Treatment Decisions in Lung Cancer. Pneumologie, 71 (3). S. 151 - 164. STUTTGART: GEORG THIEME VERLAG KG. ISSN 1438-8790

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Abstract

Personalized, individualized, targeted therapy has successfully found entrance in the palliative treatment of lung cancer as they enable a personalized and individualized strategy going ahead with biomarker testing. Due to the crescending amount of predictive molecular and immunhistochemical analyses at different time points during therapy the need for more and actual tumor tissue increases; however these samples cannot always be obtained without major discomfort for the patients. Therefore, analyses from blood, the so called, liquid biopsy, is an alternative or additional method. Activating mutations in the EGFR gene and the inhibitory mutation T790M can already be detected from blood during clinical routine. This review presents the status of liquid biopsy for diagnosis, prognosis and as predictive parameter during the course of therapy in lung cancer and gives an outlook on future developments.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Brueckl, W. M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Wirtz, R. M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Bertsch, T. UNSPECIFIED UNSPECIFIED UNSPECIFIED Ficker, J. H. UNSPECIFIED UNSPECIFIED UNSPECIFIED Jung, A. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-239330
DOI:	10.1055/s-0042-123803
Journal or Publication Title:	Pneumologie
Volume:	71
Number:	3
Page Range:	S. 151 - 164
Date:	2017
Publisher:	GEORG THIEME VERLAG KG
Place of Publication:	STUTTGART
ISSN:	1438-8790
Language:	German
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language CIRCULATING TUMOR-CELLS; GROWTH-FACTOR RECEPTOR; TYROSINE KINASE INHIBITORS; METASTATIC BREAST-CANCER; EGFR MUTATION; NSCLC PATIENTS; OPEN-LABEL; FREE DNA; COLORECTAL-CANCER; BLOOD-PLATELETS Multiple languages Respiratory System Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/23933