Cordes, Joachim, Bechdolf, Andreas, Engelke, Christina, Kahl, Kai G., Balijepalli, Chakrapani, Loesch, Christian, Klosterkoetter, Joachim, Wagner, Michael ORCID: 0000-0003-2589-6440, Maier, Wolfgang, Heinz, Andreas ORCID: 0000-0001-5405-9065, de Millas, Walter, Gaebel, Wolfgang, Winterer, Georg, Janssen, Birgit, Schmidt-Kraepelin, Christian, Schneider, Frank ORCID: 0000-0003-1557-7956, Lambert, Martin, Juckel, Georg, Wobrock, Thomas, Riedel, Michael and Moebus, Susanne (2017). Prevalence of metabolic syndrome in female and male patients at risk of psychosis. Schizophr. Res., 181. S. 38 - 43. AMSTERDAM: ELSEVIER. ISSN 1573-2509

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Abstract

Metabolic Syndrome (MetS) is one of the most common factors underlying the high rate of mortality observed in patients with schizophrenia. Recent research on this topic revealed that many of the patients studied were, in fact, in a medicated state. As such, it is unclear whether MetS is causally associated with the disorder itself or the medication used to treat it. In this study, patients with a clinically high risk of expressing first episode psychosis (CHR) were examined regarding the prevalence of MetS. N = 144 unmedicated and antipsychotic-naive CHR patients, aged between 18 and 42 years and suffering from unmanifested prodromal symptoms, were compared with a cohort of N = 3995 individuals from the German Metabolic and Cardiovascular Risk Study (GEMCAS). A slightly higher prevalence of individual MetS criteria was observed in the CHR group compared to the GEMCAS sample; specifically, the following were noted: a higher blood pressure (35.0% vs. 28.0%), increased waist circumference (17.6% vs. 15.1%), and increased fasting blood glucose (9.4% vs. 4.0%) in CHR patients. Additionally, the rate of reduced HDL cholesterol concentrations was lower in the control group (20.2% vs. 13.3%). (C) 2016 Elsevier B.V. All rights reserved.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Cordes, JoachimUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bechdolf, AndreasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Engelke, ChristinaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kahl, Kai G.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Balijepalli, ChakrapaniUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Loesch, ChristianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Klosterkoetter, JoachimUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wagner, MichaelUNSPECIFIEDorcid.org/0000-0003-2589-6440UNSPECIFIED
Maier, WolfgangUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Heinz, AndreasUNSPECIFIEDorcid.org/0000-0001-5405-9065UNSPECIFIED
de Millas, WalterUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gaebel, WolfgangUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Winterer, GeorgUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Janssen, BirgitUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schmidt-Kraepelin, ChristianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schneider, FrankUNSPECIFIEDorcid.org/0000-0003-1557-7956UNSPECIFIED
Lambert, MartinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Juckel, GeorgUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wobrock, ThomasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Riedel, MichaelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Moebus, SusanneUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-239375
DOI: 10.1016/j.schres.2016.09.012
Journal or Publication Title: Schizophr. Res.
Volume: 181
Page Range: S. 38 - 43
Date: 2017
Publisher: ELSEVIER
Place of Publication: AMSTERDAM
ISSN: 1573-2509
Language: English
Faculty: Faculty of Management, Economy and Social Sciences
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
DRUG-NAIVE PATIENTS; ANTIPSYCHOTIC MEDICATION; SCHIZOPHRENIA; MORTALITY; METAANALYSIS; 1ST-EPISODE; ASSOCIATION; DISORDER; PEOPLE; COUNTYMultiple languages
PsychiatryMultiple languages
Refereed: Yes
URI: http://kups.ub.uni-koeln.de/id/eprint/23937

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