Universität zu Köln

Bratec, Satja Mulej, Xie, Xiyao, Wang, Yijun, Schilbach, Leonhard ORCID: 0000-0001-5547-8309, Zimmer, Claus, Wohlschlaeger, Afra M., Riedl, Valentin ORCID: 0000-0002-2861-8449 and Sorg, Christian (2017). Cognitive emotion regulation modulates the balance of competing influences on ventral striatal aversive prediction error signals. Neuroimage, 147. S. 650 - 658. SAN DIEGO: ACADEMIC PRESS INC ELSEVIER SCIENCE. ISSN 1095-9572

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Abstract

Cognitive emotion regulation (CER) is a critical human ability to face aversive emotional stimuli in a flexible way, via recruitment of specific prefrontal brain circuits. Animal research reveals a central role of ventral striatum in emotional behavior, for both aversive conditioning, with striatum signaling aversive prediction errors (aPE), and for integrating competing influences of distinct striatal inputs from regions such as the prefrontal cortex (PFC), amygdala, hippocampus and ventral tegmental area (VTA). Translating these ventral striatal findings from animal research to human CER, we hypothesized that successful CER would affect the balance of competing influences of striatal afferents on striatal aPE signals, in a way favoring PFC as opposed to subcortical (i.e., non-isocortical) striatal inputs. Using aversive Pavlovian conditioning with and without CER during fMRI, we found that during CER, superior regulators indeed reduced the modulatory impact of subcortical striatal afferents (hippocampus, amygdala and VTA) on ventral striatal aPE signals, while keeping the PFC impact intact. In contrast, inferior regulators showed an opposite pattern. Our results demonstrate that ventral striatal aPE signals and associated competing modulatory inputs are critical mechanisms underlying successful cognitive regulation of aversive emotions in humans.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Bratec, Satja Mulej UNSPECIFIED UNSPECIFIED UNSPECIFIED Xie, Xiyao UNSPECIFIED UNSPECIFIED UNSPECIFIED Wang, Yijun UNSPECIFIED UNSPECIFIED UNSPECIFIED Schilbach, Leonhard UNSPECIFIED orcid.org/0000-0001-5547-8309 UNSPECIFIED Zimmer, Claus UNSPECIFIED UNSPECIFIED UNSPECIFIED Wohlschlaeger, Afra M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Riedl, Valentin UNSPECIFIED orcid.org/0000-0002-2861-8449 UNSPECIFIED Sorg, Christian UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-239718
DOI:	10.1016/j.neuroimage.2016.12.078
Journal or Publication Title:	Neuroimage
Volume:	147
Page Range:	S. 650 - 658
Date:	2017
Publisher:	ACADEMIC PRESS INC ELSEVIER SCIENCE
Place of Publication:	SAN DIEGO
ISSN:	1095-9572
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language INDIVIDUAL-DIFFERENCES; HIPPOCAMPAL; MOTIVATION; AMYGDALA; HUMANS; FMRI Multiple languages Neurosciences; Neuroimaging; Radiology, Nuclear Medicine & Medical Imaging Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/23971