Universität zu Köln

Haverkampf, Sonja, Heider, Judith, Weiss, Katharina T., Berneburg, Mark, Karrer, Sigrid, Schreml, Stephan ORCID: 0000-0002-2820-1942, Haubner, Frank, Ettl, Tobias, Schreml, Julia, Hedtrich, Sarah, von Suesskind-Schwendi, Marietta and Dissemond, Joachim (2017). NHE1 expression at wound margins increases time-dependently during physiological healing. Exp. Dermatol., 26 (2). S. 124 - 127. HOBOKEN: WILEY-BLACKWELL. ISSN 1600-0625

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Abstract

Wound repair is an orchestrated process, encompassing the phases of inflammation, proliferation and tissue remodeling. In this context, sodium hydrogen exchanger 1 (NHE1) is crucial to epidermal barrier integrity and acidification. Recently, we found that extracellular pH (pHe) on wound surfaces is dramatically increased initially after barrier disruption, and that pHe decreases gradually during physiological healing. Additionally, we have shown that spatial NHE1-patterns account for pHe-gradients on surfaces of chronic wounds. Here, we show that NHE1-expression is very low at margins initially after wounding and that it increases massively during the time-course of physiolgical healing. This finding is in accordance with the decrease of pHe on wound surfaces, which we reported on in previous works. Thus, we show that NHE1 is an interesting target when it comes to modification of surface pHe on wounds, both acute and chronic, and that NHE1 is time-dependently regulated in physiological healing.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Haverkampf, Sonja UNSPECIFIED UNSPECIFIED UNSPECIFIED Heider, Judith UNSPECIFIED UNSPECIFIED UNSPECIFIED Weiss, Katharina T. UNSPECIFIED UNSPECIFIED UNSPECIFIED Berneburg, Mark UNSPECIFIED UNSPECIFIED UNSPECIFIED Karrer, Sigrid UNSPECIFIED UNSPECIFIED UNSPECIFIED Schreml, Stephan UNSPECIFIED orcid.org/0000-0002-2820-1942 UNSPECIFIED Haubner, Frank UNSPECIFIED UNSPECIFIED UNSPECIFIED Ettl, Tobias UNSPECIFIED UNSPECIFIED UNSPECIFIED Schreml, Julia UNSPECIFIED UNSPECIFIED UNSPECIFIED Hedtrich, Sarah UNSPECIFIED UNSPECIFIED UNSPECIFIED von Suesskind-Schwendi, Marietta UNSPECIFIED UNSPECIFIED UNSPECIFIED Dissemond, Joachim UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-240924
DOI:	10.1111/exd.13097
Journal or Publication Title:	Exp. Dermatol.
Volume:	26
Number:	2
Page Range:	S. 124 - 127
Date:	2017
Publisher:	WILEY-BLACKWELL
Place of Publication:	HOBOKEN
ISSN:	1600-0625
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language REPAIR; DYNAMICS Multiple languages Dermatology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/24092