Universität zu Köln

Weiss, Katharina T., Fante, Matthias, Koehl, Gudrun, Schreml, Julia, Haubner, Frank, Kreutz, Marina, Haverkampf, Sonja, Berneburg, Mark and Schreml, Stephan ORCID: 0000-0002-2820-1942 (2017). Proton-sensing G protein-coupled receptors as regulators of cell proliferation and migration during tumor growth and wound healing. Exp. Dermatol., 26 (2). S. 127 - 133. HOBOKEN: WILEY. ISSN 1600-0625

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Abstract

Dysregulation of pH is a feature of both tumor growth and tissue repair. In tumors, microenvironmental changes, like in lactate metabolism, lead to altered intra- and extracellular pH (pHi, pHe) and vice versa. In wounds, barrier disruption results in extensive variations in pHe on the wound surface. It is known that altered extracellular proton concentrations have a major impact on cell turnover and migration as well as on the metabolic activity of cells involved in tumor spread and wound closure. The proton-sensing G protein-coupled receptors (GPCRs) GPR4, GPR65 (TDAG8), GPR68 (OGR1) and GPR132 (G2A) are activated via a decrease in pHe and transduce this signal to molecular intracellular pathways. Based on the current knowledge, we speculate on the role of proton-sensing GPCRs in wound healing and on their potential as mechanistic linkers of tumor growth and tissue repair.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Weiss, Katharina T. UNSPECIFIED UNSPECIFIED UNSPECIFIED Fante, Matthias UNSPECIFIED UNSPECIFIED UNSPECIFIED Koehl, Gudrun UNSPECIFIED UNSPECIFIED UNSPECIFIED Schreml, Julia UNSPECIFIED UNSPECIFIED UNSPECIFIED Haubner, Frank UNSPECIFIED UNSPECIFIED UNSPECIFIED Kreutz, Marina UNSPECIFIED UNSPECIFIED UNSPECIFIED Haverkampf, Sonja UNSPECIFIED UNSPECIFIED UNSPECIFIED Berneburg, Mark UNSPECIFIED UNSPECIFIED UNSPECIFIED Schreml, Stephan UNSPECIFIED orcid.org/0000-0002-2820-1942 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-240930
DOI:	10.1111/exd.13209
Journal or Publication Title:	Exp. Dermatol.
Volume:	26
Number:	2
Page Range:	S. 127 - 133
Date:	2017
Publisher:	WILEY
Place of Publication:	HOBOKEN
ISSN:	1600-0625
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language RETRACTED ARTICLE. SEE; AIRWAY SMOOTH-MUSCLE; EXTRACELLULAR ACIDIFICATION; LACTIC-ACID; CANCER PREVENTION; MICE DEFICIENT; PH; TDAG8; OGR1; IMPACT Multiple languages Dermatology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/24093