Universität zu Köln

Bleckwenn, Markus, Kleineidam, Luca, Wagner, Michael ORCID: 0000-0003-2589-6440, Jessen, Frank, Weyerer, Siegfried, Werle, Jochen, Wiese, Birgitt, Luehmann, Dagmar, Posselt, Tina, Koenig, Hans-Helmut, Brettschneider, Christian ORCID: 0000-0002-5280-1075, Moesch, Edelgard, Weeg, Dagmar, Fuchs, Angela, Pentzek, Michael, Luck, Tobias ORCID: 0000-0001-7551-4397, Riedel-Heller, Steffi G., Maier, Wolfgang and Scherer, Martin (2017). Impact of coronary heart disease on cognitive decline in Alzheimer's disease: a prospective longitudinal cohort study in primary care. Br. J. Gen. Pract., 67 (655). S. E111 - 7. LONDON: ROYAL COLL GENERAL PRACTITIONERS. ISSN 1478-5242

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Abstract

Background Arteriosclerotic disorders increase the risk of dementia. As they have common causes and risk factors, coronary heart disease (CHD) could influence the course of dementia. Aim To determine whether CHD increases the speed of cognitive decline in Alzheimer's disease, and to discuss the potential for secondary cardiovascular prevention to modify this decline. Design and setting Prospective multicentre cohort study in general practices in six cities in Germany. Method Participants were patients with probable mildto- moderate Alzheimer's dementia or mixed dementia (n = 118; mean age 85.6 [+/- 3.4] years, range 80-96 years). The authors assessed the presence of CHD according to the family physicians' diagnosis. Cognitive performance was measured during home visits for up to 3 years in intervals of 6 months, using Mini Mental State Examination (MMSE) and Clinical Dementia Rating Sum of Boxes (CDR-SoB). The authors also recorded whether patients died in the observation period. Results At baseline, 65 patients (55%) had CHD and/ or a heart condition following a myocardial infarction. The presence of CHD accelerated cognitive decline (MMSE, P<0.05) by about 66%, and reduced cognitive-functional ability (CDR-SoB, P<0.05) by about 83%, but had no impact on survival. Conclusion The study shows that CHD has a significant influence on cognitive decline in older patients with late-onset dementia. The dementia process might therefore be positively influenced by cardiovascular prevention, and this possible effect should be further investigated.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Bleckwenn, Markus UNSPECIFIED UNSPECIFIED UNSPECIFIED Kleineidam, Luca UNSPECIFIED UNSPECIFIED UNSPECIFIED Wagner, Michael UNSPECIFIED orcid.org/0000-0003-2589-6440 UNSPECIFIED Jessen, Frank UNSPECIFIED UNSPECIFIED UNSPECIFIED Weyerer, Siegfried UNSPECIFIED UNSPECIFIED UNSPECIFIED Werle, Jochen UNSPECIFIED UNSPECIFIED UNSPECIFIED Wiese, Birgitt UNSPECIFIED UNSPECIFIED UNSPECIFIED Luehmann, Dagmar UNSPECIFIED UNSPECIFIED UNSPECIFIED Posselt, Tina UNSPECIFIED UNSPECIFIED UNSPECIFIED Koenig, Hans-Helmut UNSPECIFIED UNSPECIFIED UNSPECIFIED Brettschneider, Christian UNSPECIFIED orcid.org/0000-0002-5280-1075 UNSPECIFIED Moesch, Edelgard UNSPECIFIED UNSPECIFIED UNSPECIFIED Weeg, Dagmar UNSPECIFIED UNSPECIFIED UNSPECIFIED Fuchs, Angela UNSPECIFIED UNSPECIFIED UNSPECIFIED Pentzek, Michael UNSPECIFIED UNSPECIFIED UNSPECIFIED Luck, Tobias UNSPECIFIED orcid.org/0000-0001-7551-4397 UNSPECIFIED Riedel-Heller, Steffi G. UNSPECIFIED UNSPECIFIED UNSPECIFIED Maier, Wolfgang UNSPECIFIED UNSPECIFIED UNSPECIFIED Scherer, Martin UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-241548
DOI:	10.3399/bjgp16X688813
Journal or Publication Title:	Br. J. Gen. Pract.
Volume:	67
Number:	655
Page Range:	S. E111 - 7
Date:	2017
Publisher:	ROYAL COLL GENERAL PRACTITIONERS
Place of Publication:	LONDON
ISSN:	1478-5242
Language:	English
Faculty:	Faculty of Management, Economy and Social Sciences
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language CARDIOVASCULAR RISK-FACTORS; ELDERLY-PATIENTS; APOLIPOPROTEIN-E; DEMENTIA; PREVALENCE; ATHEROSCLEROSIS; ETIOLOGY; STATINS; SCALE Multiple languages Primary Health Care; Medicine, General & Internal Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/24154