Universität zu Köln

Loupy, A., Haas, M., Solez, K., Racusen, L., Glotz, D., Seron, D., Nankivell, B. J., Colvin, R. B., Afrouzian, M., Akalin, E., Alachkar, N., Bagnasco, S., Becker, J. U., Cornell, L., Drachenberg, C., Dragun, D., de Kort, H., Gibson, I. W., Kraus, E. S., Lefaucheur, C., Legendre, C., Liapis, H., Muthukumar, T., Nickeleit, V., Orandi, B., Park, W., Rabant, M., Randhawa, P., Reed, E. F., Roufosse, C., Seshan, S. V., Sis, B., Singh, H. K., Schinstock, C., Tambur, A., Zeevi, A. and Mengel, M. (2017). The Banff 2015 Kidney Meeting Report: Current Challenges in Rejection Classification and Prospects for Adopting Molecular Pathology. Am. J. Transplant., 17 (1). S. 28 - 42. HOBOKEN: WILEY-BLACKWELL. ISSN 1600-6143

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Abstract

The XIII Banff meeting, held in conjunction the Canadian Society of Transplantation in Vancouver, Canada, reviewed the clinical impact of updates of C4d-negative antibody-mediated rejection (ABMR) from the 2013 meeting, reports from active Banff Working Groups, the relationships of donor-specific antibody tests (anti-HLA and non-HLA) with transplant histopathology, and questions of molecular transplant diagnostics. The use of transcriptome gene sets, their resultant diagnostic classifiers, or common key genes to supplement the diagnosis and classification of rejection requires further consensus agreement and validation in biopsies. Newly introduced concepts include the i-IFTA score, comprising inflammation within areas of fibrosis and atrophy and acceptance of transplant arteriolopathy within the descriptions of chronic active T cell-mediated rejection (TCMR) or chronic ABMR. The pattern of mixed TCMR and ABMR was increasingly recognized. This report also includes improved definitions of TCMR and ABMR in pancreas transplants with specification of vascular lesions and prospects for defining a vascularized composite allograft rejection classification. The goal of the Banff process is ongoing integration of advances in histologic, serologic, and molecular diagnostic techniques to produce a consensus-based reporting system that offers precise composite scores, accurate routine diagnostics, and applicability to next-generation clinical trials. In this article, the Banff consortium presents the most updated version of the kidney, pancreas, and VCA transplant rejection classification and prospects for implementing intragraft molecular assessment. See the companion report on page 42.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Loupy, A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Haas, M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Solez, K. UNSPECIFIED UNSPECIFIED UNSPECIFIED Racusen, L. UNSPECIFIED UNSPECIFIED UNSPECIFIED Glotz, D. UNSPECIFIED UNSPECIFIED UNSPECIFIED Seron, D. UNSPECIFIED UNSPECIFIED UNSPECIFIED Nankivell, B. J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Colvin, R. B. UNSPECIFIED UNSPECIFIED UNSPECIFIED Afrouzian, M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Akalin, E. UNSPECIFIED UNSPECIFIED UNSPECIFIED Alachkar, N. UNSPECIFIED UNSPECIFIED UNSPECIFIED Bagnasco, S. UNSPECIFIED UNSPECIFIED UNSPECIFIED Becker, J. U. UNSPECIFIED UNSPECIFIED UNSPECIFIED Cornell, L. UNSPECIFIED UNSPECIFIED UNSPECIFIED Drachenberg, C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Dragun, D. UNSPECIFIED UNSPECIFIED UNSPECIFIED de Kort, H. UNSPECIFIED UNSPECIFIED UNSPECIFIED Gibson, I. W. UNSPECIFIED UNSPECIFIED UNSPECIFIED Kraus, E. S. UNSPECIFIED UNSPECIFIED UNSPECIFIED Lefaucheur, C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Legendre, C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Liapis, H. UNSPECIFIED UNSPECIFIED UNSPECIFIED Muthukumar, T. UNSPECIFIED UNSPECIFIED UNSPECIFIED Nickeleit, V. UNSPECIFIED UNSPECIFIED UNSPECIFIED Orandi, B. UNSPECIFIED UNSPECIFIED UNSPECIFIED Park, W. UNSPECIFIED UNSPECIFIED UNSPECIFIED Rabant, M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Randhawa, P. UNSPECIFIED UNSPECIFIED UNSPECIFIED Reed, E. F. UNSPECIFIED UNSPECIFIED UNSPECIFIED Roufosse, C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Seshan, S. V. UNSPECIFIED UNSPECIFIED UNSPECIFIED Sis, B. UNSPECIFIED UNSPECIFIED UNSPECIFIED Singh, H. K. UNSPECIFIED UNSPECIFIED UNSPECIFIED Schinstock, C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Tambur, A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Zeevi, A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Mengel, M. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-242888
DOI:	10.1111/ajt.14107
Journal or Publication Title:	Am. J. Transplant.
Volume:	17
Number:	1
Page Range:	S. 28 - 42
Date:	2017
Publisher:	WILEY-BLACKWELL
Place of Publication:	HOBOKEN
ISSN:	1600-6143
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language ANTIBODY-MEDIATED REJECTION; DONOR-SPECIFIC ANTIBODIES; TRANSPLANTATION BIFQUIT REPRODUCIBILITY; RENAL-ALLOGRAFT REJECTION; NON-HLA ANTIBODIES; MICROARRAY DIAGNOSIS; COMPLEMENT-BINDING; QUALITY-ASSURANCE; GRAFT FAILURE; BIOPSIES Multiple languages Surgery; Transplantation Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/24288