Mesquita, Ana, Cardenal-Munoz, Elena ORCID: 0000-0003-4757-9323, Dominguez, Eunice, Munoz-Braceras, Sandra, Nunez-Corcuera, Beatriz, Phillips, Ben A., Tabara, Luis C., Xiong, Qiuhong, Coria, Roberto, Eichinger, Ludwig ORCID: 0000-0003-1594-6117, Golstein, Pierre ORCID: 0000-0003-1750-3483, King, Jason S., Soldati, Thierry, Vincent, Olivier and Escalante, Ricardo ORCID: 0000-0001-8547-531X (2017). Autophagy in Dictyostelium: Mechanisms, regulation and disease in a simple biomedical model. Autophagy, 13 (1). S. 24 - 41. PHILADELPHIA: TAYLOR & FRANCIS INC. ISSN 1554-8635

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Abstract

Autophagy is a fast-moving field with an enormous impact on human health and disease. Understanding the complexity of the mechanism and regulation of this process often benefits from the use of simple experimental models such as the social amoeba Dictyostelium discoideum. Since the publication of the first review describing the potential of D. discoideum in autophagy, significant advances have been made that demonstrate both the experimental advantages and interest in using this model. Since our previous review, research in D. discoideum has shed light on the mechanisms that regulate autophagosome formation and contributed significantly to the study of autophagy-related pathologies. Here, we review these advances, as well as the current techniques to monitor autophagy in D. discoideum. The comprehensive bioinformatics search of autophagic proteins that was a substantial part of the previous review has not been revisited here except for those aspects that challenged previous predictions such as the composition of the Atg1 complex. In recent years our understanding of, and ability to investigate, autophagy in D. discoideum has evolved significantly and will surely enable and accelerate future research using this model.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Mesquita, AnaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Cardenal-Munoz, ElenaUNSPECIFIEDorcid.org/0000-0003-4757-9323UNSPECIFIED
Dominguez, EuniceUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Munoz-Braceras, SandraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Nunez-Corcuera, BeatrizUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Phillips, Ben A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Tabara, Luis C.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Xiong, QiuhongUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Coria, RobertoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Eichinger, LudwigUNSPECIFIEDorcid.org/0000-0003-1594-6117UNSPECIFIED
Golstein, PierreUNSPECIFIEDorcid.org/0000-0003-1750-3483UNSPECIFIED
King, Jason S.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Soldati, ThierryUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Vincent, OlivierUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Escalante, RicardoUNSPECIFIEDorcid.org/0000-0001-8547-531XUNSPECIFIED
URN: urn:nbn:de:hbz:38-242997
DOI: 10.1080/15548627.2016.1226737
Journal or Publication Title: Autophagy
Volume: 13
Number: 1
Page Range: S. 24 - 41
Date: 2017
Publisher: TAYLOR & FRANCIS INC
Place of Publication: PHILADELPHIA
ISSN: 1554-8635
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
NECROTIC CELL-DEATH; CYCLIC DI-GMP; MYCOBACTERIUM-MARINUM INFECTION; DIFFERENTIATION-INDUCING FACTOR; CHOREA-ACANTHOCYTOSIS; ATG1 KINASE; LEGIONELLA-PNEUMOPHILA; ENDOPLASMIC-RETICULUM; SELECTIVE AUTOPHAGY; SALMONELLA-TYPHIMURIUMMultiple languages
Cell BiologyMultiple languages
Refereed: Yes
URI: http://kups.ub.uni-koeln.de/id/eprint/24299

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