Erdogan, Alican J. and Riemer, Jan (2017). Mitochondrial disulfide relay and its substrates: mechanisms in health and disease. Cell Tissue Res., 367 (1). S. 59 - 73. NEW YORK: SPRINGER. ISSN 1432-0878
Full text not available from this repository.Abstract
Eukaryotic cells harbor membrane-enclosed compartments to spatially separate different biochemical processes. As a result, proteins that become synthesized in the cytosol but fulfill their function in another compartment require translocation machineries. In the intermembrane space (IMS) of mitochondria, the mitochondrial disulfide relay is responsible for the import of many soluble proteins in an oxidation-dependent manner. These IMS proteins carry out important tasks and therefore their import, folding and maintenance are crucial for the remainder of the cell. In this review, we first describe the machinery for oxidative protein folding in the IMS and then focus on recent developments, which especially concern the mammalian machinery, its substrates and its physiological role.
Item Type: | Journal Article | ||||||||||||
Creators: |
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URN: | urn:nbn:de:hbz:38-243059 | ||||||||||||
DOI: | 10.1007/s00441-016-2481-z | ||||||||||||
Journal or Publication Title: | Cell Tissue Res. | ||||||||||||
Volume: | 367 | ||||||||||||
Number: | 1 | ||||||||||||
Page Range: | S. 59 - 73 | ||||||||||||
Date: | 2017 | ||||||||||||
Publisher: | SPRINGER | ||||||||||||
Place of Publication: | NEW YORK | ||||||||||||
ISSN: | 1432-0878 | ||||||||||||
Language: | English | ||||||||||||
Faculty: | Faculty of Mathematics and Natural Sciences | ||||||||||||
Divisions: | Faculty of Mathematics and Natural Sciences > Department of Chemistry > Institute of Biochemistry | ||||||||||||
Subjects: | no entry | ||||||||||||
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Refereed: | Yes | ||||||||||||
URI: | http://kups.ub.uni-koeln.de/id/eprint/24305 |
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