Universität zu Köln

Zierk, Jakob, Arzideh, Farhad, Haeckel, Rainer, Cario, Holger ORCID: 0000-0002-6923-488X, Fruehwald, Michael C., Gross, Hans-Juergen, Gscheidmeier, Thomas, Hoffmann, Reinhard ORCID: 0000-0003-1514-1183, Krebs, Alexander, Lichtinghagen, Ralf, Neumann, Michael, Ruf, Hans-Georg, Steigerwald, Udo, Streichert, Thomas, Rascher, Wolfgang, Metzler, Markus ORCID: 0000-0002-4523-1676 and Rauh, Manfred (2017). Pediatric reference intervals for alkaline phosphatase. Clin. Chem. Lab. Med., 55 (1). S. 102 - 111. BERLIN: WALTER DE GRUYTER GMBH. ISSN 1437-4331

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Abstract

Background: Interpretation of alkaline phosphatase activity in children is challenging due to extensive changes with growth and puberty leading to distinct sex- and age-specific dynamics. Continuous percentile charts from birth to adulthood allow accurate consideration of these dynamics and seem reasonable for an analyte as closely linked to growth as alkaline phosphatase. However, the ethical and practical challenges unique to pediatric reference intervals have restricted the creation of such percentile charts, resulting in limitations when clinical decisions are based on alkaline phosphatase activity. Methods: We applied an indirect method to generate percentile charts for alkaline phosphatase activity using clinical laboratory data collected during the clinical care of patients. A total of 361,405 samples from 124,440 patients from six German tertiary care centers and one German laboratory service provider measured between January 2004 and June 2015 were analyzed. Measurement of alkaline phosphatase activity was performed on Roche Cobas analyzers using the IFCC's photometric method. Results: We created percentile charts for alkaline phosphatase activity in girls and boys from birth to 18 years which can be used as reference intervals. Additionally, data tables of age- and sex-specific percentile values allow the incorporation of these results into laboratory information systems. Conclusions: The percentile charts provided enable the appropriate differential diagnosis of changes in alkaline phosphatase activity due to disease and changes due to physiological development. After local validation, integration of the provided percentile charts into result reporting facilitates precise assessment of alkaline phosphatase dynamics in pediatrics.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Zierk, Jakob UNSPECIFIED UNSPECIFIED UNSPECIFIED Arzideh, Farhad UNSPECIFIED UNSPECIFIED UNSPECIFIED Haeckel, Rainer UNSPECIFIED UNSPECIFIED UNSPECIFIED Cario, Holger UNSPECIFIED orcid.org/0000-0002-6923-488X UNSPECIFIED Fruehwald, Michael C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Gross, Hans-Juergen UNSPECIFIED UNSPECIFIED UNSPECIFIED Gscheidmeier, Thomas UNSPECIFIED UNSPECIFIED UNSPECIFIED Hoffmann, Reinhard UNSPECIFIED orcid.org/0000-0003-1514-1183 UNSPECIFIED Krebs, Alexander UNSPECIFIED UNSPECIFIED UNSPECIFIED Lichtinghagen, Ralf UNSPECIFIED UNSPECIFIED UNSPECIFIED Neumann, Michael UNSPECIFIED UNSPECIFIED UNSPECIFIED Ruf, Hans-Georg UNSPECIFIED UNSPECIFIED UNSPECIFIED Steigerwald, Udo UNSPECIFIED UNSPECIFIED UNSPECIFIED Streichert, Thomas UNSPECIFIED UNSPECIFIED UNSPECIFIED Rascher, Wolfgang UNSPECIFIED UNSPECIFIED UNSPECIFIED Metzler, Markus UNSPECIFIED orcid.org/0000-0002-4523-1676 UNSPECIFIED Rauh, Manfred UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-243089
DOI:	10.1515/cclm-2016-0318
Journal or Publication Title:	Clin. Chem. Lab. Med.
Volume:	55
Number:	1
Page Range:	S. 102 - 111
Date:	2017
Publisher:	WALTER DE GRUYTER GMBH
Place of Publication:	BERLIN
ISSN:	1437-4331
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language BIOCHEMICAL ANALYTES; SCHOOL-CHILDREN; CORD BLOOD; HEALTHY; ESTABLISHMENT; ADOLESCENTS; INFANTS; MARKERS; CALCIUM; BONE Multiple languages Medical Laboratory Technology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/24308