Universität zu Köln

Salama, Mahmoud ORCID: 0000-0002-0282-8018, Isachenko, Vladimir, Isachenko, Evgenia, Rahimi, Gohar and Mallmann, Peter (2017). Advances in fertility preservation of female patients with hematological malignancies. Expert Rev. Hematol., 10 (11). S. 951 - 961. ABINGDON: TAYLOR & FRANCIS LTD. ISSN 1747-4094

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Abstract

Introduction: The most common forms of hematological malignancies that occur in female reproductive years are lymphoma and leukemia.Areas covered: Several aggressive gonadotoxic regimens such as alkylating chemotherapy and total body irradiation are used frequently in treatment of lymphoma and leukemia leading to subsequent iatrogenic premature ovarian failure and fertility loss. In such cases, female fertility preservation options should be offered in advance.Expert commentary: In order to preserve fertility of young women and girls with lymphoma and leukemia, several established, experimental, and debatable options can be offered before starting chemotherapy and radiotherapy. However, each of those female fertility preservation options has both advantages and disadvantages and may not be suitable for all patients. That is why a fertility preservation strategy should be individualized and tailored distinctively for each patient in order to be effective. Artificial human ovary is a novel experimental in vitro technology to produce mature oocytes that could be the safest option to preserve and restore fertility of young women and girls with hematological malignancies especially when other fertility preservation options are not feasible or contraindicated. Further research and studies are needed to improve the results of artificial human ovary and establish it in clinical practice.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Salama, Mahmoud UNSPECIFIED orcid.org/0000-0002-0282-8018 UNSPECIFIED Isachenko, Vladimir UNSPECIFIED UNSPECIFIED UNSPECIFIED Isachenko, Evgenia UNSPECIFIED UNSPECIFIED UNSPECIFIED Rahimi, Gohar UNSPECIFIED UNSPECIFIED UNSPECIFIED Mallmann, Peter UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-243366
DOI:	10.1080/17474086.2017.1371009
Journal or Publication Title:	Expert Rev. Hematol.
Volume:	10
Number:	11
Page Range:	S. 951 - 961
Date:	2017
Publisher:	TAYLOR & FRANCIS LTD
Place of Publication:	ABINGDON
ISSN:	1747-4094
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language OVARIAN TISSUE CRYOPRESERVATION; IN-VITRO MATURATION; BREAST-CANCER PATIENTS; CLINICAL-PRACTICE GUIDELINES; ARTIFICIAL OVARY; OOCYTE MATURATION; PROTECTING OVARIES; GONAD SUPPRESSION; LUTEAL-PHASE; AUTOLOGOUS TRANSPLANTATION Multiple languages Hematology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/24336