Volz, L. J., Vollmer, M., Michely, J., Fink, G. R., Rothwell, J. C. and Grefkes, C. (2017). Time-dependent functional role of the contralesional motor cortex after stroke. NeuroImage-Clin., 16. S. 165 - 175. OXFORD: ELSEVIER SCI LTD. ISSN 2213-1582

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Abstract

After stroke, movements of the paretic hand rely on altered motor network dynamics typically including additional activation of the contralesional primary motor cortex (M1). The functional implications of contralesional M1 recruitment to date remain a matter of debate. We here assessed the role of contralesional M1 in 12 patients recovering from a first-ever stroke using online transcranial magnetic stimulation (TMS): Short bursts of TMS were administered over contralesional M1 or a control site (occipital vertex) while patients performed different motor tasks with their stroke-affected hand. In the early subacute phase (1-2 weeks post-stroke), we observed significant improvements in maximum finger tapping frequency when interfering with contralesional M1, while maximum grip strength and speeded movement initiation remained unaffected. After > 3 months of motor recovery, disruption of contralesional M1 activity did not interfere with performance in any of the three tasks, similar to what we observed in healthy controls. In patients with mild to moderate motor deficits, contralesional M1 has a task-and time-specific negative influence on motor performance of the stroke-affected hand. Our results help to explain previous contradicting findings on the role of contralesional M1 in recovery of function.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Volz, L. J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Vollmer, M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Michely, J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Fink, G. R.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rothwell, J. C.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Grefkes, C.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-243835
DOI: 10.1016/j.nicl.2017.07.024
Journal or Publication Title: NeuroImage-Clin.
Volume: 16
Page Range: S. 165 - 175
Date: 2017
Publisher: ELSEVIER SCI LTD
Place of Publication: OXFORD
ISSN: 2213-1582
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
INTERHEMISPHERIC INHIBITION; CORTICAL CONNECTIVITY; MAGNETIC STIMULATION; PREMOTOR CORTEX; RECOVERY; ACTIVATION; MOVEMENT; LESION; BRAIN; REORGANIZATIONMultiple languages
NeuroimagingMultiple languages
Refereed: Yes
URI: http://kups.ub.uni-koeln.de/id/eprint/24383

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