Universität zu Köln

Zhao, Jiangang, Li, Jiahui, Schloesser, Hans A., Popp, Felix, Popp, Marie Christine, Alakus, Hakan, Jauch, Karl-Walter, Bruns, Christiane J. and Zhao, Yue (2017). Targeting Cancer Stem Cells and Their Niche: Current Therapeutic Implications and Challenges in Pancreatic Cancer. Stem Cells Int., 2017. LONDON: HINDAWI LTD. ISSN 1687-9678

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Abstract

Cancer stem cells (CSCs) have been identified as a subpopulation of stem-like cancer cells with the ability of self-renewal and differentiation in hematological malignancies and solid tumors. Pancreatic cancer is one of the most lethal cancers worldwide. CSCs are thought to be responsible for cancer initiation, progression, metastasis, chemoresistance, and recurrence in pancreatic cancer. In this review, we summarize the characteristics of pancreatic CSCs and discuss the mechanisms involved in resistance to chemotherapy, the interactions with the niche, and the potential role in cancer immunoediting. We propose that immunotherapy targeting pancreatic CSCs, in combination with targeting the niche components, may provide a novel treatment strategy to eradicate pancreatic CSCs and hence improve outcomes in pancreatic cancer.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Zhao, Jiangang UNSPECIFIED UNSPECIFIED UNSPECIFIED Li, Jiahui UNSPECIFIED UNSPECIFIED UNSPECIFIED Schloesser, Hans A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Popp, Felix UNSPECIFIED UNSPECIFIED UNSPECIFIED Popp, Marie Christine UNSPECIFIED UNSPECIFIED UNSPECIFIED Alakus, Hakan UNSPECIFIED UNSPECIFIED UNSPECIFIED Jauch, Karl-Walter UNSPECIFIED UNSPECIFIED UNSPECIFIED Bruns, Christiane J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Zhao, Yue UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-245807
DOI:	10.1155/2017/6012810
Journal or Publication Title:	Stem Cells Int.
Volume:	2017
Date:	2017
Publisher:	HINDAWI LTD
Place of Publication:	LONDON
ISSN:	1687-9678
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language SIGNALING PATHWAYS; SUPPRESSOR-CELLS; STELLATE CELLS; IMMUNE ESCAPE; ACINAR-CELL; IDENTIFICATION; RESISTANCE; IMMUNOSURVEILLANCE; CHEMOTHERAPY; ACTIVATION Multiple languages Cell & Tissue Engineering Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/24580