Universität zu Köln

Bollschweiler, Elfriede, Plum, Patrick, Moenig, Stefan P. and Hoelscher, Arnulf H. (2017). Current and future treatment options for esophageal cancer in the elderly. Expert Opin. Pharmacother., 18 (10). S. 1001 - 1011. ABINGDON: TAYLOR & FRANCIS LTD. ISSN 1744-7666

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Abstract

Introduction: Esophageal cancer is the eighth most common cancer globally and has the sixth worst prognosis because of its aggressiveness and poor survival. Data regarding cancer treatment in older patients is limited because the elderly have been under-represented in clinical trials. Therefore, we reviewed the existing literature regarding treatment results for elderly patients (70+ years).Areas covered: We used pubmed to analyze the actual literature according to elderly esophageal cancer patients with subheading of incidence, esophagectomy, chemoradiation or chemotherapy. The main points of interest were treatment options for patients with Barrett's esophagus or early carcinoma, advanced tumor stages, and inoperable cancer.Expert opinion: The incidence of esophageal cancer has been increasing over the past thirty years, with a rapid increase of esophageal adenocarcinoma in Western industrialized nations. Patients aged over 60years have been particularly affected. In this review, we have shown that elderly patients with esophageal cancer have various alternatives for adequate treatment. Clinical evaluation of comorbidity is necessary to make treatment decisions. Therapeutic options for early carcinomas are endoscopic or surgical resection. For elderly patients with advanced carcinomas, preoperative chemoradiation or chemotherapy should be discussed.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Bollschweiler, Elfriede UNSPECIFIED UNSPECIFIED UNSPECIFIED Plum, Patrick UNSPECIFIED UNSPECIFIED UNSPECIFIED Moenig, Stefan P. UNSPECIFIED UNSPECIFIED UNSPECIFIED Hoelscher, Arnulf H. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-246014
DOI:	10.1080/14656566.2017.1334764
Journal or Publication Title:	Expert Opin. Pharmacother.
Volume:	18
Number:	10
Page Range:	S. 1001 - 1011
Date:	2017
Publisher:	TAYLOR & FRANCIS LTD
Place of Publication:	ABINGDON
ISSN:	1744-7666
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language SQUAMOUS-CELL CARCINOMA; LONG-TERM SURVIVAL; NEOADJUVANT CHEMORADIATION; PERIOPERATIVE CHEMOTHERAPY; RESECTABLE ESOPHAGEAL; HISTOPATHOLOGIC RESPONSE; ESOPHAGOGASTRIC CANCER; ENDOSCOPIC MANAGEMENT; BARRETTS-ESOPHAGUS; PROGNOSTIC IMPACT Multiple languages Pharmacology & Pharmacy Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/24601