Dolscheid-Pommerich, Ramona C., Manekeller, Steffen, Walgenbach-Bruenagel, Gisela, Kalff, Joerg C., Hartmann, Gunther ORCID: 0000-0003-1021-2018, Wagner, Birgit Stoffel and Holdenrieder, Stefan
(2017).
Clinical Performance of CEA, CA19-9, CA15-3, CA125 and AFP in Gastrointestinal Cancer Using LOCI (TM)-based Assays.
Anticancer Res., 37 (1).
S. 353 - 360.
ATHENS:
INT INST ANTICANCER RESEARCH.
ISSN 1791-7530
Abstract
Background/Aim: Few data are available regarding the clinical performance of LOCI (TM)-based tumor marker assays. We investigated the diagnostic power of carcinogenic antigen, carbohydrate antigen 19-9, carbohydrate antigen 15-3, carbohydrate antigen 125 and alpha-fetoprotein for detection of gastrointestinal (GI) cancer. Patients and Methods: We analyzed sera from 204 patients (107 with GI cancer, 73 with benign GI diseases and 24 healthy controls) using the Dimension (TM) Vista1500 analyzer. Results: Levels of biomarkers in healthy controls were in the expected ranges and were only slightly higher in benign GI controls. Established tumor-type-associated markers were elevated in specific cancer types and discriminated well between cancer and benign controls. Best performance was found for CEA in colorectal cancer (area under the curve=0.84, sensitivity=51.7% at 95% specificity vs. benign), CA19-9 in gallbladder/pancreatic cancer (AUC=0.85, sensitivity=60.6%) and AFP in liver cancer (AUC=0.87, sensitivity=68.4%). Conclusion: Our study demonstrated the high diagnostic power of well-known biomarkers. LOCI (TM)-based tumor marker assays give reliable results in routine diagnostics.
Item Type: | Journal Article | ||||||||||||||||||||||||||||||||
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URN: | urn:nbn:de:hbz:38-247964 | ||||||||||||||||||||||||||||||||
DOI: | 10.21873/anticanres.11329 | ||||||||||||||||||||||||||||||||
Journal or Publication Title: | Anticancer Res. | ||||||||||||||||||||||||||||||||
Volume: | 37 | ||||||||||||||||||||||||||||||||
Number: | 1 | ||||||||||||||||||||||||||||||||
Page Range: | S. 353 - 360 | ||||||||||||||||||||||||||||||||
Date: | 2017 | ||||||||||||||||||||||||||||||||
Publisher: | INT INST ANTICANCER RESEARCH | ||||||||||||||||||||||||||||||||
Place of Publication: | ATHENS | ||||||||||||||||||||||||||||||||
ISSN: | 1791-7530 | ||||||||||||||||||||||||||||||||
Language: | English | ||||||||||||||||||||||||||||||||
Faculty: | Unspecified | ||||||||||||||||||||||||||||||||
Divisions: | Unspecified | ||||||||||||||||||||||||||||||||
Subjects: | no entry | ||||||||||||||||||||||||||||||||
Uncontrolled Keywords: |
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Refereed: | Yes | ||||||||||||||||||||||||||||||||
URI: | http://kups.ub.uni-koeln.de/id/eprint/24796 |
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