Universität zu Köln

Chung, Wing H., van Dijk, Elon H. C., Mohabati, Danial, Dijkman, Greet, Yzer, Suzanne, de Jong, Eiko K., Fauser, Sascha, Schlingemann, Reinier O., Hoyng, Carel B. and Boon, Camiel J. F. (2017). Neovascular age-related macular degeneration without drusen in the fellow eye: clinical spectrum and therapeutic outcome. Clin. Ophthalmol., 11. S. 63 - 71. ALBANY: DOVE MEDICAL PRESS LTD. ISSN 1177-5483

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Abstract

Purpose: To investigate the clinical characteristics and therapeutic outcome of patients with neovascular age-related macular degeneration (nAMD) in 1 eye, without drusen in the fellow eye. Patients and methods: Medical records of 381 patients were analyzed to identify the cases. The main outcomes included Early Treatment Diabetic Retinopathy Study (ETDRS) best-corrected visual acuity (BCVA) and change in central retinal thickness (CRT). These parameters were reviewed at baseline, first follow-up visit, and after 6, 12, and 24 months. Results: Out of 381 patients, 29 cases (8%) were included (of whom 3 had polypoidal choroidal vasculopathy [PCV]) who were treated with anti-vascular endothelial growth factor (anti-VEGF) therapy which was supplemented by photodynamic therapy (PDT) in the PCV patients. Overall, no statistically significant change in mean BCVA was observed during follow-up. BCVA improved or remained stable (defined as a gain in BCVA, a stable BCVA, or a loss of <5 ETDRS letters) in 22 patients (76%), and 7 patients (23%) had lost >= 5 ETDRS letters at final follow-up. A gain of >= 15 ETDRS letters at final follow-up was seen in 5 patients (17%). Mean CRT had decreased significantly with 99 mu m (P < 0.001) at 24 months after the initial visit. Conclusion: There is a clinical spectrum of nAMD that is not associated with drusen in the fellow eye. Patients with nAMD without drusen in the fellow eye respond to anti-VEGF treatment and, in cases of PCV, to supplemental PDT. The pathophysiology of this spectrum of nAMD may be different from drusen-associated age-related macular degeneration.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Chung, Wing H. UNSPECIFIED UNSPECIFIED UNSPECIFIED van Dijk, Elon H. C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Mohabati, Danial UNSPECIFIED UNSPECIFIED UNSPECIFIED Dijkman, Greet UNSPECIFIED UNSPECIFIED UNSPECIFIED Yzer, Suzanne UNSPECIFIED UNSPECIFIED UNSPECIFIED de Jong, Eiko K. UNSPECIFIED UNSPECIFIED UNSPECIFIED Fauser, Sascha UNSPECIFIED UNSPECIFIED UNSPECIFIED Schlingemann, Reinier O. UNSPECIFIED UNSPECIFIED UNSPECIFIED Hoyng, Carel B. UNSPECIFIED UNSPECIFIED UNSPECIFIED Boon, Camiel J. F. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-248162
DOI:	10.2147/OPTH.S122568
Journal or Publication Title:	Clin. Ophthalmol.
Volume:	11
Page Range:	S. 63 - 71
Date:	2017
Publisher:	DOVE MEDICAL PRESS LTD
Place of Publication:	ALBANY
ISSN:	1177-5483
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language POLYPOIDAL CHOROIDAL VASCULOPATHY; BEAVER DAM EYE; BASAL DEPOSITS; MACULOPATHY; CLASSIFICATION; PREVALENCE; DISEASE; SYSTEM Multiple languages Ophthalmology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/24816