Bouteloup, V., Sabin, C., Mocroft, A., Gras, L., Pantazis, N., Le Moing, V., d'Arminio Monforte, A., Mary-Krause, M., Roca, B., Miro, J. M., Battegay, M., Brockmeyer, N., Berenguer, J., Morlat, P., Obel, N., De Wit, S., Faetkenheuer, G., Zangerle, R., Ghosn, J., Perez-Hoyos, S., Campbell, M., Prins, M., Chene, G., Meyer, L., Dorrucci, M., Torti, C. and Thiebaut, R. (2017). Reference curves for CD4 T-cell count response to combination antiretroviral therapy in HIV-1-infected treatment-naive patients. HIV Med., 18 (1). S. 33 - 45. HOBOKEN: WILEY-BLACKWELL. ISSN 1468-1293

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Abstract

ObjectivesThe aim of this work was to provide a reference for the CD4 T-cell count response in the early months after the initiation of combination antiretroviral therapy (cART) in HIV-1-infected patients. MethodsAll patients in the Collaboration of Observational HIV Epidemiological Research Europe (COHERE) cohort who were aged 18 years and started cART for the first time between 1 January 2005 and 1 January 2010 and who had at least one available measurement of CD4 count and a viral load 50 HIV-1 RNA copies/mL at 6 months ( 3 months) after cART initiation were included in the study. Unadjusted and adjusted references curves and predictions were obtained using quantile regressions. ResultsA total of 28 992 patients were included in the study. The median CD4 T-cell count at treatment initiation was 249 [interquartile range (IQR) 150, 336] cells/L. The median observed CD4 counts at 6, 9 and 12 months were 382 (IQR 256, 515), 402 (IQR 274, 543) and 420 (IQR 293, 565) cells/L. The two main factors explaining the variation of CD4 count at 6 months were AIDS stage and CD4 count at cART initiation. A CD4 count increase of 100 cells/mL is generally required in order that patients stay on track' (i.e. with a CD4 count at the same percentile as when they started), with slightly higher gains required for those starting with CD4 counts in the higher percentiles. Individual predictions adjusted for factors influencing CD4 count were more precise. ConclusionsReference curves aid the evaluation of the immune response early after antiretroviral therapy initiation that leads to viral control.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Bouteloup, V.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sabin, C.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mocroft, A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gras, L.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pantazis, N.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Le Moing, V.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
d'Arminio Monforte, A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mary-Krause, M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Roca, B.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Miro, J. M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Battegay, M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Brockmeyer, N.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Berenguer, J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Morlat, P.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Obel, N.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
De Wit, S.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Faetkenheuer, G.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Zangerle, R.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ghosn, J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Perez-Hoyos, S.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Campbell, M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Prins, M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Chene, G.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Meyer, L.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Dorrucci, M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Torti, C.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Thiebaut, R.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-248358
DOI: 10.1111/hiv.12389
Journal or Publication Title: HIV Med.
Volume: 18
Number: 1
Page Range: S. 33 - 45
Date: 2017
Publisher: WILEY-BLACKWELL
Place of Publication: HOBOKEN
ISSN: 1468-1293
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
HIV-INFECTED ADULTS; TERM IMMUNOLOGICAL RESPONSE; COHORT; SUPPRESSION; RECOVERY; DETERMINANTS; INDIVIDUALS; HOMEOSTASIS; INCREASES; LIFEMultiple languages
Infectious DiseasesMultiple languages
Refereed: Yes
URI: http://kups.ub.uni-koeln.de/id/eprint/24835

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