Demuth, Hans-Ulrich, Dijkhuizen, Rick M., Farr, Tracy D., Gelderblom, Mathias, Horsburgh, Karen ORCID: 0000-0002-9620-3691, Iadecola, Costantino ORCID: 0000-0001-9797-073X, Mcleod, Damian D., Michalski, Dominik, Murphy, Tim H., Orbe, Josune ORCID: 0000-0001-6300-7670, Otte, Willem M. ORCID: 0000-0003-1511-6834, Petzold, Gabor C., Plesnila, Nikolaus, Reiser, Georg, Reymann, Klaus G., Rueger, Maria A., Saur, Dorothee ORCID: 0000-0002-1808-0913, Savitz, Sean I., Schilling, Stephan, Spratt, Neil J., Turner, Renee J., Vemuganti, Raghu, Vivien, Denis, Yepes, Manuel, Zille, Marietta ORCID: 0000-0002-0609-8956 and Boltze, Johannes (2017). Recent progress in translational research on neurovascular and neurodegenerative disorders. Restor. Neurol. Neurosci., 35 (1). S. 87 - 104. AMSTERDAM: IOS PRESS. ISSN 1878-3627

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Abstract

The already established and widely used intravenous application of recombinant tissue plasminogen activator as a re-opening strategy for acute vessel occlusion in ischemic stroke was recently added by mechanical thrombectomy, representing a fundamental progress in evidence-based medicine to improve the patient's outcome. This has been paralleled by a swift increase in our understanding of pathomechanisms underlying many neurovascular diseases and most prevalent forms of dementia. Taken together, these current advances offer the potential to overcome almost two decades of marginally successful translational research on stroke and dementia, thereby spurring the entire field of translational neuroscience. Moreover, they may also pave the way for the renaissance of classical neuroprotective paradigms. This review reports and summarizes some of the most interesting and promising recent achievements in neurovascular and dementia research. It highlights sessions from the 9th International Symposium on Neuroprotection and Neurorepair that have been discussed from April 19th to 22nd in Leipzig, Germany. To acknowledge the emerging culture of interdisciplinary collaboration and research, special emphasis is given on translational stories ranging from fundamental research on neurodeand -regeneration to late stage translational or early stage clinical investigations.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Demuth, Hans-UlrichUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Dijkhuizen, Rick M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Farr, Tracy D.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gelderblom, MathiasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Horsburgh, KarenUNSPECIFIEDorcid.org/0000-0002-9620-3691UNSPECIFIED
Iadecola, CostantinoUNSPECIFIEDorcid.org/0000-0001-9797-073XUNSPECIFIED
Mcleod, Damian D.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Michalski, DominikUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Murphy, Tim H.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Orbe, JosuneUNSPECIFIEDorcid.org/0000-0001-6300-7670UNSPECIFIED
Otte, Willem M.UNSPECIFIEDorcid.org/0000-0003-1511-6834UNSPECIFIED
Petzold, Gabor C.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Plesnila, NikolausUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Reiser, GeorgUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Reymann, Klaus G.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rueger, Maria A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Saur, DorotheeUNSPECIFIEDorcid.org/0000-0002-1808-0913UNSPECIFIED
Savitz, Sean I.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schilling, StephanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Spratt, Neil J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Turner, Renee J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Vemuganti, RaghuUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Vivien, DenisUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Yepes, ManuelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Zille, MariettaUNSPECIFIEDorcid.org/0000-0002-0609-8956UNSPECIFIED
Boltze, JohannesUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-248486
DOI: 10.3233/RNN-160690
Journal or Publication Title: Restor. Neurol. Neurosci.
Volume: 35
Number: 1
Page Range: S. 87 - 104
Date: 2017
Publisher: IOS PRESS
Place of Publication: AMSTERDAM
ISSN: 1878-3627
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
DIRECT-CURRENT STIMULATION; ISCHEMIC-STROKE; INTRACRANIAL-PRESSURE; AMYLOID-BETA; IN-VIVO; COGNITIVE DECLINE; RECEPTOR CD36; ANIMAL-MODEL; TIME WINDOW; THROMBECTOMYMultiple languages
NeurosciencesMultiple languages
Refereed: Yes
URI: http://kups.ub.uni-koeln.de/id/eprint/24848

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