Universität zu Köln

Schweigel, Hardy, Wicht, Michael and Schwendicke, Falk (2016). Salivary and pellicle proteome: A datamining analysis. Sci Rep, 6. LONDON: NATURE PUBLISHING GROUP. ISSN 2045-2322

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Abstract

We aimed to comprehensively compare two compartmented oral proteomes, the salivary and the dental pellicle proteome. Systematic review and datamining was used to obtain the physico-chemical, structural, functional and interactional properties of 1,515 salivary and 60 identified pellicle proteins. Salivary and pellicle proteins did not differ significantly in their aliphatic index, hydrophaty, instability index, or isoelectric point. Pellicle proteins were significantly more charged at low and high pH and were significantly smaller (10-20 kDa) than salivary proteins. Protein structure and solvent accessible molecular surface did not differ significantly. Proteins of the pellicle were more phosphorylated and glycosylated than salivary proteins. Ion binding and enzymatic activities also differed significantly. Protein-protein-ligand interaction networks relied on few key proteins. The identified differences between salivary and pellicle proteins could guide proteome compartmentalization and result in specialized functionality. Key proteins could be potential targets for diagnostic or therapeutic application.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Schweigel, Hardy UNSPECIFIED UNSPECIFIED UNSPECIFIED Wicht, Michael UNSPECIFIED UNSPECIFIED UNSPECIFIED Schwendicke, Falk UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-252550
DOI:	10.1038/srep38882
Journal or Publication Title:	Sci Rep
Volume:	6
Date:	2016
Publisher:	NATURE PUBLISHING GROUP
Place of Publication:	LONDON
ISSN:	2045-2322
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language ACQUIRED ENAMEL PELLICLE; MASS-SPECTROMETRY; HUMAN INTERACTOME; PLASMA PROTEOMES; BIOLOGY; DIMENSIONS; COLLECTION; ADSORPTION; EVOLUTION; PATHWAYS Multiple languages Multidisciplinary Sciences Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/25255