Universität zu Köln

Yu, Xiaojie, Odenthal, Margarete and Fries, Jochen W. U. (2016). Exosomes as miRNA Carriers: Formation-Function-Future. Int. J. Mol. Sci., 17 (12). BASEL: MDPI. ISSN 1422-0067

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Abstract

Exosomes, which are one of the smallest extracellular vesicles released from cells, have been shown to carry different nucleic acids, including microRNAs (miRNAs). miRNAs significantly regulate cell growth and metabolism by posttranscriptional inhibition of gene expression. The rapidly changing understanding of exosomes' formation and function in delivering miRNAs from cell to cell has prompted us to review current knowledge in exosomal miRNA secretion mechanisms as well as possible therapeutic applications for personalized medicine.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Yu, Xiaojie UNSPECIFIED UNSPECIFIED UNSPECIFIED Odenthal, Margarete UNSPECIFIED UNSPECIFIED UNSPECIFIED Fries, Jochen W. U. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-253729
DOI:	10.3390/ijms17122028
Journal or Publication Title:	Int. J. Mol. Sci.
Volume:	17
Number:	12
Date:	2016
Publisher:	MDPI
Place of Publication:	BASEL
ISSN:	1422-0067
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language HEPARAN-SULFATE PROTEOGLYCANS; CIRCULATING MICRORNAS; CELL-SURFACE; LIVER-INJURY; STEM-CELLS; EXTRACELLULAR VESICLES; POTENTIAL BIOMARKERS; PROFILING REVEALS; TISSUE INHIBITOR; PROSTATE-CANCER Multiple languages Biochemistry & Molecular Biology; Chemistry, Multidisciplinary Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/25372