Larenas Linnemann, D. E. S., Singh, J., Rosario, N., Esch, R., Matta, J. J., Maspero, J., Michels, A. and Moesges, R. (2016). Similar biological activity in skin prick test for Oralair((R)) (8200 BAU) and Grazax((R)) (6200 BAU) reinforces effective SLIT dosing level. Allergy, 71 (12). S. 1782 - 1787. HOBOKEN: WILEY. ISSN 1398-9995
Full text not available from this repository.Abstract
In Europe, allergen extracts are standardized based on skin prick wheal size in 20-30 allergic subjects. To understand the biological activity of clinically effective Sublingual immunotherapy, we used this method to determine the biological activity of solution and tablet Timothy grass pollen (TIM) extracts, compared to an FDA-approved extract (Reference) of 10 000 BAU/ml. Blinded, quadruplicate skin prick tests with concentrate and three serial half-log dilutions allowed the construction of a semilogarithmic regression line per extract. Bioequivalent allergy units (BAU) values were obtained from the comparison with reference. Extracts and dilutions showed a neat linear dose response (all: R-2 > 0.98) in 33 rhinitis patients. Relative potencies: Staloral((R)) 12 000 BAU/ml, Soluprick((R)) 10 300 BAU/ml, Oralair((R)) 8200 BAU, and Grazax((R)) 6200 BAU. Even though all extract concentrates differed in wheal size (P = 0.01-0.001), Grazax((R)) producing a 25% smaller wheal size than Oralair((R)), and the biological activity of these clinically effective TIM tablets led in the same range (6200-8200 BAU; 0.92-1.23 cm(2)). SLIT dose-finding studies for other pollens might start with allergen extracts producing 1.1 cm(2) wheal surface.
Item Type: | Journal Article | ||||||||||||||||||||||||||||||||||||
Creators: |
|
||||||||||||||||||||||||||||||||||||
URN: | urn:nbn:de:hbz:38-254534 | ||||||||||||||||||||||||||||||||||||
DOI: | 10.1111/all.12998 | ||||||||||||||||||||||||||||||||||||
Journal or Publication Title: | Allergy | ||||||||||||||||||||||||||||||||||||
Volume: | 71 | ||||||||||||||||||||||||||||||||||||
Number: | 12 | ||||||||||||||||||||||||||||||||||||
Page Range: | S. 1782 - 1787 | ||||||||||||||||||||||||||||||||||||
Date: | 2016 | ||||||||||||||||||||||||||||||||||||
Publisher: | WILEY | ||||||||||||||||||||||||||||||||||||
Place of Publication: | HOBOKEN | ||||||||||||||||||||||||||||||||||||
ISSN: | 1398-9995 | ||||||||||||||||||||||||||||||||||||
Language: | English | ||||||||||||||||||||||||||||||||||||
Faculty: | Unspecified | ||||||||||||||||||||||||||||||||||||
Divisions: | Unspecified | ||||||||||||||||||||||||||||||||||||
Subjects: | no entry | ||||||||||||||||||||||||||||||||||||
Uncontrolled Keywords: |
|
||||||||||||||||||||||||||||||||||||
Refereed: | Yes | ||||||||||||||||||||||||||||||||||||
URI: | http://kups.ub.uni-koeln.de/id/eprint/25453 |
Downloads
Downloads per month over past year
Altmetric
Export
Actions (login required)
![]() |
View Item |