Universität zu Köln

Gomez, Juan Daniel Castillo, Hagenbach, Adelheid and Abram, Ulrich (2016). Propargyl-Substituted Thiocarbamoylbenzamidines of Technetium and Rhenium: Steps towards Bioconjugation with Use of Click Chemistry. Eur. J. Inorg. Chem. (35). S. 5427 - 5435. WEINHEIM: WILEY-V C H VERLAG GMBH. ISSN 1099-0682

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Abstract

A new propargyl-substituted thiocarbamoylbenzamidine has been synthesized. The compound acts as a tetradentate ligand and forms stable complexes with {(ReO)-O-V}(3+) and {(TcO)-O-V}(3+) cores. Click couplings of the resulting complexes with benzylazide lead to prototype triazole derivatives, which were analyzed by NMR and IR spectroscopy and mass spectrometry, as well as by X-ray diffraction. A similar coupling procedure has been applied to an azido-modified angiotensin-II peptide, which gives the desired rhenium(V) bioconjugate in good yield. The ease of this coupling and the stability of the conjugate recommend such tetradentate thiocarbamoylbenzamidines also for clinically relevant bioconjugates with Tc-99m.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Gomez, Juan Daniel Castillo UNSPECIFIED UNSPECIFIED UNSPECIFIED Hagenbach, Adelheid UNSPECIFIED UNSPECIFIED UNSPECIFIED Abram, Ulrich UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-254786
DOI:	10.1002/ejic.201601039
Journal or Publication Title:	Eur. J. Inorg. Chem.
Number:	35
Page Range:	S. 5427 - 5435
Date:	2016
Publisher:	WILEY-V C H VERLAG GMBH
Place of Publication:	WEINHEIM
ISSN:	1099-0682
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language COMPLEXES; TRIDENTATE; PEPTIDE; BENZAMIDINES Multiple languages Chemistry, Inorganic & Nuclear Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/25478