Universität zu Köln

Balke, M., Wunderlich, G., Brunn, A., Fink, G. R. and Lehmann, H. C. (2016). Chronic Inflammatory Demyelinating Polyneuropathy. Forschritte Neurol. Psychiatr., 84 (12). S. 756 - 769. STUTTGART: GEORG THIEME VERLAG KG. ISSN 1439-3522

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Abstract

Chronic inflammatory demyelinating polyneuropathy (CIDP) is a chronic progressive or relapsing autoimmune neuropathy with heterogeneous clinical presentation. Symptoms typically include symmetrical, proximal and/or distal paresis and sensory loss. Atypical CIDP variants are increasingly recognized, including subtypes with rapid onset as well as variants with pure sensory, focal or marked asymmetrical deficits. Diagnosis is established by compatible symptoms, characteristic electrophysiological features and cerebrospinal fluid analysis. In unequivocal cases, inflammatory infiltrates in sural nerve biopsy support the diagnosis. Recent studies suggest that diagnostic imaging techniques such as MRI and nerve ultrasound may become useful tools for establishing the diagnosis. First-line therapies include immunoglobulines, steroids, and plasmapheresis. Immunosuppressant agents and monoclonal antibodies are used in therapy-refractory cases or as cortison-saving agents.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Balke, M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Wunderlich, G. UNSPECIFIED UNSPECIFIED UNSPECIFIED Brunn, A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Fink, G. R. UNSPECIFIED UNSPECIFIED UNSPECIFIED Lehmann, H. C. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-254806
DOI:	10.1055/s-0042-120226
Journal or Publication Title:	Forschritte Neurol. Psychiatr.
Volume:	84
Number:	12
Page Range:	S. 756 - 769
Date:	2016
Publisher:	GEORG THIEME VERLAG KG
Place of Publication:	STUTTGART
ISSN:	1439-3522
Language:	German
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language GUILLAIN-BARRE-SYNDROME; CORNEAL CONFOCAL MICROSCOPY; INTRAVENOUS IMMUNOGLOBULIN TREATMENT; RANDOMIZED CONTROLLED-TRIAL; BOCHUM ULTRASOUND SCORE; SUBCUTANEOUS IMMUNOGLOBULIN; PLASMA-EXCHANGE; MYCOPHENOLATE-MOFETIL; DOUBLE-BLIND; NEUROIMMUNOLOGICAL DISORDERS Multiple languages Clinical Neurology; Psychiatry Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/25480