Morfeld, P. and Spallek, M. (2016). Hazard assessment by exposure to several carcinogenic working materials. Supplements and enhancements. Zentralblatt Arb. Arb. Ergon., 66 (6). S. 337 - 345. HEIDELBERG: SPRINGER HEIDELBERG. ISSN 2198-0713
Full text not available from this repository.Abstract
We analyzed the validity of simple summation formulae with which a common effect of different occupational exposures could be mapped to the same cancer endpoint. Our paper published in this journal relied on the assumptions of a deterministic response and binary exposures. The German Federal Environmental Agency organized an external review of our paper. Although the reviewers agreed with our main conclusion that simple summation formulae cannot have a general validity, they raised questions that we would like to inform the scientific public about and are addressed in this addendum. We demonstrate that the main statements in Morfeld and Spallek 2015 remain valid even if the exposures are defined on an interval scale, the binary response is probabilistic or if the analyzed response types are restricted to adverse types. We clarify that excess risks and differences in excess risks are not probabilities according to the Kolmogorov axioms. Simple summation formulae are therefore not justified, not even to estimate the lower bounds for excess risks.
| Item Type: | Journal Article | ||||||||||||
| Creators: |
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| URN: | urn:nbn:de:hbz:38-257035 | ||||||||||||
| DOI: | 10.1007/s40664-016-0118-4 | ||||||||||||
| Journal or Publication Title: | Zentralblatt Arb. Arb. Ergon. | ||||||||||||
| Volume: | 66 | ||||||||||||
| Number: | 6 | ||||||||||||
| Page Range: | S. 337 - 345 | ||||||||||||
| Date: | 2016 | ||||||||||||
| Publisher: | SPRINGER HEIDELBERG | ||||||||||||
| Place of Publication: | HEIDELBERG | ||||||||||||
| ISSN: | 2198-0713 | ||||||||||||
| Language: | German | ||||||||||||
| Faculty: | Unspecified | ||||||||||||
| Divisions: | Unspecified | ||||||||||||
| Subjects: | no entry | ||||||||||||
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| Refereed: | Yes | ||||||||||||
| URI: | http://kups.ub.uni-koeln.de/id/eprint/25703 |
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