Universität zu Köln

Groneck, Laura, Quaas, Alexander, Hallek, Michael, Zander, Thomas and Weihrauch, Martin R. (2016). Ultrasound-guided core needle biopsies for workup of lymphadenopathy and lymphoma. Eur. J. Haematol., 97 (4). S. 379 - 387. HOBOKEN: WILEY. ISSN 1600-0609

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Abstract

BackgroundFor the histopathological diagnosis of lymphoma, lymph node excision biopsies are regarded as standard of care. In contrast, for the diagnosis of carcinoma and deep-seated tumors, core needle biopsies (CNBs) are accepted as a sufficient sampling method. We evaluated a diagnostic algorithm for peripheral lymphadenopathy starting with ultrasound-guided CNB followed by excisional biopsy in ambiguous cases. MethodsWe performed ultrasound-guided CNB of peripheral lymph nodes and subcutaneous tumors in patients with lymphadenopathy in routine care and analyzed its accuracy, complication rate, and the impact of needle sizes on results. ResultsFrom 138 patients, 132 samples were technically adequate. In 121 patients, CNB provided a clinically actionable diagnosis (76 lymphoma, 30 carcinoma, 15 non-malignant diagnoses). A total of 54 patients had a secondary biopsy. Inconclusive diagnoses were rare with two false-positive and two false-negative non-Hodgkin's lymphoma, and higher for Hodgkin's lymphoma with five false-negative cases. The rate of complications was low. Needle size did not significantly influence results. ConclusionUltrasound-guided CNBs are a safe, quick, and valid tool for the workup of lymphadenopathy. Yet, a benign diagnosis from CNB must be completed by a secondary biopsy if clinical presentation suggests malignant disease.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Groneck, Laura UNSPECIFIED UNSPECIFIED UNSPECIFIED Quaas, Alexander UNSPECIFIED UNSPECIFIED UNSPECIFIED Hallek, Michael UNSPECIFIED UNSPECIFIED UNSPECIFIED Zander, Thomas UNSPECIFIED UNSPECIFIED UNSPECIFIED Weihrauch, Martin R. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-259537
DOI:	10.1111/ejh.12742
Journal or Publication Title:	Eur. J. Haematol.
Volume:	97
Number:	4
Page Range:	S. 379 - 387
Date:	2016
Publisher:	WILEY
Place of Publication:	HOBOKEN
ISSN:	1600-0609
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language ASPIRATION-CYTOLOGY; HODGKINS-LYMPHOMA; DIAGNOSIS; PATHOLOGY; IMPACT; HEAD; CLASSIFICATION; GUIDELINES; EXPERIENCE; ACCURACY Multiple languages Hematology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/25953