Maurer, C., Langerbeins, P., Bahlo, J., Cramer, P., Fink, A. M., Pflug, N., Engelke, A., von Tresckow, J., Kovacs, G., Stilgenbauer, S., Wendtner, C-M, Mueller, L., Ritgen, M., Seiler, T., Fischer, K., Hallek, M. and Eichhorst, B. (2016). Effect of first-line treatment on second primary malignancies and Richter's transformation in patients with CLL. Leukemia, 30 (10). S. 2019 - 2026. LONDON: NATURE PUBLISHING GROUP. ISSN 1476-5551

Full text not available from this repository.

Abstract

This study aimed to assess the frequency of and the contributing factors for second primary malignancies (SPMs) and Richter's transformations (RTs) following first-line treatment of chronic lymphocytic leukemia within four phase II/III trials of the GCLLSG evaluating fludarabine (F) vs F+cyclophosphamide (FC), chlorambucil vs F, FC without or with rituximab, and bendamustine+R (BR). Among 1458 patients, 239 (16.4%) experienced either an SPM (N = 191) or a RT (N = 75). Solid tumors (N = 115; 43.2% of all second neoplasias) appeared most frequently, followed by RTs (N = 75; 28.2%). Patients showed a 1.23-fold increased risk of solid tumors in comparison to the age-matched general population from the German cancer registry. Age>65 (hazard ratio (HR) 2.1; P<0.001), male sex (HR 1.7; P = 0.01), co-morbidities (HR 1.6; P = 0.01) and number of subsequent treatments >= 1 (HR 12.1; P<0.001) showed an independent adverse prognostic impact on SPM-free survival. Serum thymidine kinase > 10 U/l at trial enrollment (HR 3.9; P = 0.02), non-response to first-line treatment (HR 3.6; P<0.001) and number of subsequent treatments >= 1 (HR 30.2; P<0.001) were independently associated with increased risk for RT.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Maurer, C.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Langerbeins, P.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bahlo, J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Cramer, P.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Fink, A. M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pflug, N.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Engelke, A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
von Tresckow, J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kovacs, G.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Stilgenbauer, S.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wendtner, C-MUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mueller, L.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ritgen, M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Seiler, T.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Fischer, K.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hallek, M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Eichhorst, B.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-260608
DOI: 10.1038/leu.2016.113
Journal or Publication Title: Leukemia
Volume: 30
Number: 10
Page Range: S. 2019 - 2026
Date: 2016
Publisher: NATURE PUBLISHING GROUP
Place of Publication: LONDON
ISSN: 1476-5551
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
CHRONIC LYMPHOCYTIC-LEUKEMIA; CELL LYMPHOMA; CLINICAL CHARACTERISTICS; SINGLE-INSTITUTION; THERAPY; CANCER; FLUDARABINE; IMMUNOSUPPRESSION; CHLORAMBUCIL; RITUXIMABMultiple languages
Oncology; HematologyMultiple languages
Refereed: Yes
URI: http://kups.ub.uni-koeln.de/id/eprint/26060

Downloads

Downloads per month over past year

Altmetric

Export

Actions (login required)

View Item View Item