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Do, N. N. and Eming, S. A. (2016). Skin fibrosis: Models and mechanisms. Curr. Res. Transl. Med., 64 (4). S. 185 - 194. ISSY-LES-MOULINEAUX: ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER. ISSN 2452-3186

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Abstract

Matrix synthesis, deposition and remodeling are complex biological processes that are critical in development, maintenance of tissue homeostasis and repair of injured tissues. Disturbances in the regulation of these processes can result in severe pathological conditions which are associated with tissue fibrosis as e.g. in Scleroderma, cutaneous Graft-versus-Host-Disease, excessive scarring after trauma or carcinogenesis. Therefore, finding efficient treatments to limit skin fibrosis is of major clinical importance. However the pathogenesis underlying the development of tissue fibrosis is still not entirely resolved. In recent years progress has been made unraveling the complex cellular and molecular mechanisms that determine fibrosis. Here we provide an overview of established and more recently developed mouse models that can be used to investigate the mechanisms of skin fibrosis and to test potential therapeutic approaches. (C) 2016 Elsevier Masson SAS. All rights reserved.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Do, N. N. UNSPECIFIED UNSPECIFIED UNSPECIFIED Eming, S. A. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-261409
DOI:	10.1016/j.retram.2016.06.003
Journal or Publication Title:	Curr. Res. Transl. Med.
Volume:	64
Number:	4
Page Range:	S. 185 - 194
Date:	2016
Publisher:	ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
Place of Publication:	ISSY-LES-MOULINEAUX
ISSN:	2452-3186
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language GROWTH-FACTOR-BETA; VERSUS-HOST-DISEASE; BLEOMYCIN-INDUCED FIBROSIS; CONNECTIVE-TISSUE; EXTRACELLULAR-MATRIX; COLLAGEN-SYNTHESIS; TIGHT-SKIN; ANIMAL-MODEL; PULMONARY-FIBROSIS; SYSTEMIC-SCLEROSIS Multiple languages Medicine, Research & Experimental Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/26140