Eguchi, Kazuya, Niether, Doreen ORCID: 0000-0002-8496-4215, Wiegand, Simone ORCID: 0000-0001-6333-1956 and Kita, Rio ORCID: 0000-0002-9683-5840 (2016). Thermophoresis of cyclic oligosaccharides in polar solvents. Eur. Phys. J. E, 39 (9). NEW YORK: SPRINGER. ISSN 1292-895X

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Abstract

Cyclodextrins are cyclic oligosaccharides which are interesting as drug delivery systems, because they can be used as containers for pharmaceutical substances. We studied the Ludwig-Soret effect of alpha-, beta-, gamma- and methyl-beta-cyclodextrin in water and formamide by infrared thermal diffusion forced Rayleigh scattering (IR-TDFRS). In water the Soret coefficient, S-T, of alpha-, beta- and gamma-cyclodextrin increases with increasing temperature and shows a sign change from negative to positive around T = 35 degrees C, while S-T of methyl-beta-cyclodextrin is positive in the entire investigated temperature. In formamide S-T-values of all cyclodextrins coincide and show a slight decrease with temperature. We discuss the obtained results and relate the S-T-values to the different hydrogen bonding capabilities of the cyclodextrins and the used solvents. It turns out that the change of S-T with temperature correlates with the partition coefficient, log P, which indicates that more hydrophilic substances show a more pronounced temperature sensitivity of S-T. Additionally we obtained a surprising result measuring the refractive index contrast factor with temperature, (partial derivative n/partial derivative T)(c,p) of cyclodextrins in formamide, which might be explained by a complex formation between cyclodextrins and formamide.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Eguchi, KazuyaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Niether, DoreenUNSPECIFIEDorcid.org/0000-0002-8496-4215UNSPECIFIED
Wiegand, SimoneUNSPECIFIEDorcid.org/0000-0001-6333-1956UNSPECIFIED
Kita, RioUNSPECIFIEDorcid.org/0000-0002-9683-5840UNSPECIFIED
URN: urn:nbn:de:hbz:38-262042
DOI: 10.1140/epje/i2016-16086-5
Journal or Publication Title: Eur. Phys. J. E
Volume: 39
Number: 9
Date: 2016
Publisher: SPRINGER
Place of Publication: NEW YORK
ISSN: 1292-895X
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
FORCED RAYLEIGH-SCATTERING; THERMAL-DIFFUSION; REFRACTIVE-INDEX; CYCLODEXTRIN COMPLEXES; TEMPERATURE-DEPENDENCE; NONIONIC SURFACTANTS; CRYSTAL-STRUCTURES; GRATING TECHNIQUE; SORET; MIXTURESMultiple languages
Chemistry, Physical; Materials Science, Multidisciplinary; Physics, Applied; Polymer ScienceMultiple languages
Refereed: Yes
URI: http://kups.ub.uni-koeln.de/id/eprint/26204

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